hand2 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-481425

Gene Symbol: hand2 Gene Name: heart and neural crest derivatives expressed 2

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: hand2 assayed (11 sources)
Computed annotations: hand2 assayed (13 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (89 sources): aberrant origin of the right subclavian artery, abnormal Meckel's cartilage morphology, abnormal adrenergic neuron morphology, abnormal apical ectodermal ridge morphology, abnormal atrioventricular cushion morphology, abnormal cardiac outflow tract development, abnormal craniofacial bone morphology, abnormal digit development, abnormal enteric neuron morphology, abnormal enzyme/coenzyme level, abnormal fetal cardiomyocyte proliferation, abnormal first pharyngeal arch artery morphology, abnormal first pharyngeal arch morphology, abnormal forelimb bud morphology, abnormal forelimb morphology, abnormal forelimb zeugopod morphology, abnormal heart development, abnormal heart looping, abnormal hindlimb morphology, abnormal hindlimb zeugopod morphology, abnormal hyoid bone lesser horn morphology, abnormal interdigital cell death, abnormal limb bud morphology, abnormal limb development, abnormal malleus manubrium morphology, abnormal mandible morphology, abnormal mandibular angle morphology, abnormal middle ear ossicle morphology, abnormal neuron differentiation, abnormal palatal shelf elevation, abnormal palatal shelf fusion at midline, abnormal pharyngeal arch artery morphology, abnormal pollex morphology, abnormal presphenoid bone morphology, abnormal pterygoid bone morphology, abnormal secondary palate development, abnormal suckling behavior, abnormal sympathetic ganglion morphology, abnormal thymus development, abnormal tongue muscle morphology, abnormal tympanic ring morphology, absent heart right ventricle, absent maxillary shelf, absent myocardial trabeculae, absent pharyngeal arches, absent second pharyngeal arch artery, absent suckling reflex, absent trabeculae carneae, cardiovascular system phenotype, craniofacial phenotype, decreased cardiac muscle contractility, decreased embryo size, decreased heart left ventricle size, decreased heart right ventricle size, decreased lumbar vertebrae number, decreased somite size, decreased tympanic ring size, dilated aortic sac, dilated heart left ventricle, distended pericardium, embryo phenotype, embryonic growth retardation, embryonic lethality during organogenesis, complete penetrance, failure of palatal shelf elevation, gonial bone hypoplasia, hemimelia, incomplete somite formation, increased apoptosis, increased atrioventricular cushion size, increased embryonic tissue cell apoptosis, lethality throughout fetal growth and development, complete penetrance, limbs/digits/tail phenotype, liver vascular congestion, mandible hypoplasia, neonatal lethality, complete penetrance, nervous system phenotype, no abnormal phenotype detected, palatal shelf hypoplasia, palatal shelves fail to meet at midline, pharyngeal arch hypoplasia, poor circulation, retroesophageal right subclavian artery, short Meckel's cartilage, short mandible, small forelimb buds, small mandible, thin myocardium, tongue hypoplasia, visceral vascular congestion [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (89 sources): aberrant origin of the right subclavian artery, abnormal Meckel's cartilage morphology, abnormal adrenergic neuron morphology, abnormal apical ectodermal ridge morphology, abnormal atrioventricular cushion morphology, abnormal cardiac outflow tract development, abnormal craniofacial bone morphology, abnormal digit development, abnormal enteric neuron morphology, abnormal enzyme/coenzyme level, [+]