bmp2 Phenotypes

Summary

Expression

Phenotypes

Gene Literature (155)

XB-GENEPAGE-481828

Gene Symbol: bmp2 Gene Name: bone morphogenetic protein 2

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal axis specification (2 sources), decreased length of anterior-posterior axis (2 sources), decreased size of the head (2 sources), abnormal head morphology (1 source), abnormal pathway-restricted SMAD protein phosphorylation (1 source), absent foregut (1 source), absent liver primordium (1 source), absent lung primordium (1 source), absent ventral pancreatic bud (1 source), decreased length of trunk (1 source), decreased size of the foregut (1 source), edematous embryo (1 source), obsolete duplicated anatomical axis (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormal axis specification (2 sources), decreased length of anterior-posterior axis (2 sources), decreased size of the head (2 sources), abnormal head morphology (1 source), abnormal pathway-restricted SMAD protein phosphorylation (1 source), absent foregut (1 source), absent liver primordium (1 source), absent lung primordium (1 source), absent ventral pancreatic bud (1 source), decreased length of trunk (1 source), decreased size of the foregut (1 source), edematous embryo (1 source), obsolete duplicated anatomical axis (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: bmp2 manipulated (9 sources), bmp2 assayed (7 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + bmp2 MO (9 sources), Xla Wt + Hsa.BMP2 (2 sources), Xla Wt + bmp2 (1 source), Xla Wt + bmp2 + dvl3 MO (1 source), Xla Wt + kcp + bmp2 (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (52 sources): 11 pairs of ribs, 2-3 toe syndactyly, Anteverted nares, Aplasia/Hypoplasia of the middle phalanx of the 2nd finger, Aplasia/Hypoplasia of the middle phalanx of the 5th finger, Broad forehead, Broad hallux, Clinodactyly of the 5th finger, Conductive hearing impairment, Delayed skeletal maturation, Dental crowding, Downslanted palpebral fissures, Everted lower lip vermilion, Hallux valgus, High palate, Infantile muscular hypotonia, Long philtrum, Low-set ears, Medially deviated second toe, Midface retrusion, Narrow forehead, Obstructive sleep apnea, Paroxysmal supraventricular tachycardia, Pectus excavatum, Perimembranous ventricular septal defect, Pierre-Robin sequence, Posteriorly rotated ears, Prominent sternum, Pulmonic stenosis, Radial deviation of the 2nd finger, Sandal gap, Short 2nd finger, Short 2nd metacarpal, Short 5th metacarpal, Short foot, Short hallux, Short middle phalanx of finger, Short middle phalanx of the 5th finger, Short nose, Short stature, Short toe, Spina bifida occulta, Spondylolisthesis, Synophrys, Thin upper lip vermilion, Toenail dysplasia, Transposition of the great arteries, Triangular shaped middle phalanx of the 2nd finger, Triangular shaped middle phalanx of the 5th finger, Type A2 brachydactyly, Ulnar deviation of the 2nd finger, obsolete Anterior open bite [+]
Mouse (41 sources): abnormal cardiac epithelial to mesenchymal transition, abnormal cardiac jelly morphology, abnormal chorion morphology, abnormal fetal atrioventricular canal morphology, abnormal heart development, abnormal heart position or orientation, abnormal myocardium layer morphology, abnormal proamniotic cavity morphology, abnormal vascular development, abnormal vertebral column morphology, absent atrioventricular cushions, absent deltoid tuberosity, cardiac edema, decreased body length, decreased bone mineral content, decreased bone mineralization, decreased bone ossification, decreased bone volume, decreased embryo size, decreased litter size, decreased osteoblast cell number, decreased osteoclast cell number, decreased survivor rate, decreased trabecular bone thickness, decreased trabecular bone volume, delayed allantois development, delayed heart development, embryonic growth retardation, embryonic lethality during organogenesis, complete penetrance, embryonic lethality prior to tooth bud stage, embryonic lethality, complete penetrance, hearing/vestibular/ear phenotype, impaired osteoblast differentiation, incomplete embryo turning, incomplete rostral neuropore closure, increased or absent threshold for auditory brainstem response, kinked tail, long gestation period, no abnormal phenotype detected, open neural tube, prenatal lethality, complete penetrance [+]
View all ortholog results at Monarch