prkci Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-481944

Gene Symbol: prkci Gene Name: protein kinase C iota

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal gastrulation (1 source), abnormal head morphology (1 source), abnormal tail morphology (1 source), absent blastopore (1 source), decreased length of anterior-posterior axis (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: prkci assayed (1 source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + prkci MO (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (52 sources): abnormal cell morphology, abnormal circulating lipid level, abnormal head fold morphology, abnormal heart tube morphology, abnormal iris pigment epithelium, abnormal lens epithelium morphology, abnormal mesoderm development, abnormal pancreas secretion, abnormal podocyte morphology, abnormal podocyte polarity, abnormal podocyte slit diaphragm morphology, abnormal podocyte slit junction morphology, abnormal proximal convoluted tubule morphology, abnormal proximal-distal axis patterning, abnormal renal glomerulus morphology, abnormal retina photoreceptor morphology, abnormal rostral-caudal axis patterning, absent allantois, absent heart tube, absent photoreceptor inner segment, absent photoreceptor outer segment, absent somites, decreased adipocyte glucose uptake, decreased cardiac cell glucose uptake, decreased circulating glucose level, decreased muscle cell glucose uptake, decreased podocyte number, detached podocyte, dilated glomerular capillary, dilated renal tubules, disorganized secondary lens fibers, embryonic growth retardation, embryonic lethality, complete penetrance, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, embryonic lethality, incomplete penetrance, fused podocyte foot processes, increased circulating creatinine level, increased circulating glucose level, increased food intake, increased susceptibility to autoimmune diabetes, lethality during fetal growth through weaning, complete penetrance, pancreatic islet hyperplasia, podocyte foot process effacement, premature death, pupil opacity, renal cast, renal glomerular synechia, small allantois, small amniotic cavity, small pupils, thick embryonic epiblast [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (52 sources): abnormal cell morphology, abnormal circulating lipid level, abnormal head fold morphology, abnormal heart tube morphology, abnormal iris pigment epithelium, abnormal lens epithelium morphology, abnormal mesoderm development, abnormal pancreas secretion, abnormal podocyte morphology, abnormal podocyte polarity, [+]