abnormal heart development, abnormal hindbrain development, abnormal intersomitic vessel morphology, abnormal lipid homeostasis, abnormal midbrain development, abnormal pancreatic beta cell morphology, abnormal regulatory T cell physiology, abnormal single-positive T cell number, abnormal skin appearance, abnormal somite development, abnormal somite shape, abnormal tail morphology, abnormal visceral yolk sac morphology, abnormal vitelline vascular remodeling, abnormal vitelline vasculature morphology, absent heartbeat, absent organized vascular network, absent second pharyngeal arch, absent vitelline blood vessels, decreased T cell proliferation, decreased carbon dioxide production, decreased circulating VLDL triglyceride level, decreased circulating free fatty acids level, decreased circulating tumor necrosis factor level, decreased double-positive T cell number, decreased energy expenditure, decreased liver cholesterol level, decreased liver glycogen level, decreased liver triglyceride level, decreased respiratory quotient, decreased somite size, decreased thymocyte apoptosis, delayed heart looping, distended pericardium, embryonic growth retardation, embryonic lethality during organogenesis, complete penetrance, embryonic lethality, complete penetrance, enlarged lymph nodes, enlarged pericardium, homeostasis/metabolism phenotype, hunched posture, improved glucose tolerance, increased CD4-positive, alpha beta T cell number, increased CD8-positive, alpha-beta T cell number, increased T cell proliferation, increased anti-double stranded DNA antibody level, increased anti-nuclear antigen antibody level, increased circulating glucose level, increased hemangioma incidence, increased insulin sensitivity, increased interferon-gamma secretion, increased percent body fat/body weight, increased regulatory T cell number, increased single-positive T cell number, increased susceptibility to diet-induced obesity, increased susceptibility to induced colitis, no abnormal phenotype detected, pharyngeal arch artery hypoplasia, pharyngeal arch hypoplasia, premature death, preweaning lethality, complete penetrance, small first pharyngeal arch, small lymphoid organs, small second pharyngeal arch, small spleen