mmp2 Phenotypes

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Phenotypes

Gene Literature (31)

Nucleotides (192)

Interactants (430)

XB-GENEPAGE-482840

Gene Symbol: mmp2 Gene Name: matrix metallopeptidase 2

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: mmp2 assayed (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (82 sources): Abnormal facial shape, Abnormal form of the vertebral bodies, Abnormal hand morphology, Abnormal thorax morphology, Abnormality of the cardiovascular system, Abnormality of the ear, Abnormality of the orbital region, Ankle flexion contracture, Ankylosis of feet small joints, Antinuclear antibody positivity, Arthralgia, Arthritis, Arthropathy, Atrial septal defect, Atrioventricular block, Bicuspid aortic valve, Brachycephaly, Broad clavicles, Broad metacarpals, Broad metatarsal, Bulbous nose, C1-C2 subluxation, Camptodactyly of toe, Carpal osteolysis, Coarctation of aorta, Coarse facial features, Delayed closure of the anterior fontanelle, Delayed eruption of teeth, Distal tapering of metatarsals, Double outlet right ventricle, Finger swelling, Frontal bossing, Gait disturbance, Gingival overgrowth, Hip contracture, Hirsutism, Hypermelanotic macule, Hypertelorism, Hypertension, Hypoplasia of the maxilla, Increased susceptibility to fractures, Intellectual disability, Interphalangeal joint contracture of finger, Interphalangeal joint erosions, Iris coloboma, Kyphoscoliosis, Localized skin lesion, Metacarpal osteolysis, Metaphyseal widening, Metatarsal osteolysis, Micrognathia, Mitral valve prolapse, Narrow nasal bridge, Nodular goiter, Omphalocele, Osteolysis, Osteolysis involving bones of the lower limbs, Osteolysis involving bones of the upper limbs, Osteolysis involving tarsal bones, Osteopenia, Osteoporosis, Papilledema, Peripheral opacification of the cornea, Pes cavus, Pes planus, Polycystic ovaries, Premature thelarche, Proptosis, Protrusio acetabuli, Pterygium, Sclerotic cranial sutures, Short stature, Split hand, Subcutaneous nodule, Thickened skin, Thin metacarpal cortices, Thin metatarsal cortices, Type I diabetes mellitus, Ventricular septal defect, Vertebral compression fracture, Widened metacarpal shaft, Wrist flexion contracture [+]
Mouse (29 sources): abnormal angiogenesis, abnormal articular cartilage morphology, abnormal bone marrow cell physiology, abnormal coronal suture morphology, abnormal cranium morphology, abnormal induced retina neovascularization, abnormal lambdoid suture morphology, abnormal response to cardiac infarction, abnormal sagittal suture morphology, abnormal skeleton development, abnormal vascular smooth muscle physiology, broad snout, coronal suture sclerosis, decreased angiogenesis, decreased body size, decreased bone volume, decreased circulating glucose level, decreased osteoblast cell number, decreased osteoclast cell number, decreased tumor growth/size, dilated heart left ventricle, impaired lung alveolus development, improved glucose tolerance, increased susceptibility to experimental autoimmune encephalomyelitis, lambdoid suture sclerosis, no abnormal phenotype detected, sagittal suture sclerosis, short mandible, short maxilla [+]
View all ortholog results at Monarch