nr3c2 Phenotypes

Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Phenotypes

Gene Literature (11)

Nucleotides (75)

Interactants (97)

XB-GENEPAGE-483084

Gene Symbol: nr3c2 Gene Name: nuclear receptor subfamily 3 group C member 2

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: nr3c2 assayed (4 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (18 sources): Decreased circulating renin level, Dehydration, Diarrhea, Failure to thrive, Feeding difficulties, Hyperactive renin-angiotensin system, Hyperaldosteronism, Hyperkalemia, Hypertension, Hyponatremia, Hypotension, Increased circulating renin level, Maternal hypertension, Metabolic acidosis, Moderate albuminuria, Pseudohypoaldosteronism, Vomiting, obsolete Decreased circulating aldosterone level [+]
Mouse (30 sources): abnormal extraglomerular mesangial cell morphology, abnormal hippocampal mossy fiber morphology, abnormal juxtaglomerular apparatus morphology, abnormal juxtaglomerular cell morphology, abnormal macula densa morphology, abnormal miniature excitatory postsynaptic currents, abnormal redox activity, abnormal renal glomerulus morphology, abnormal renal sodium ion transport, abnormal renal sodium reabsorption, abnormal response to novel object, abnormal spatial learning, abnormal spatial working memory, abnormal vasoconstriction, abnormal vasodilation, behavior/neurological phenotype, cardiovascular system phenotype, decreased heart weight, decreased systemic arterial systolic blood pressure, decreased vasoconstriction, homeostasis/metabolism phenotype, increased circulating angiotensin II level, increased renin activity, increased startle reflex, increased urine sodium level, increased vasoconstriction, increased vasodilation, postnatal lethality, postnatal lethality, complete penetrance, renal/urinary system phenotype [+]
View all ortholog results at Monarch