nodal Phenotypes

Summary

Expression

Phenotypes

Gene Literature (486)

XB-GENEPAGE-483208

Gene Symbol: nodal Gene Name: nodal growth differentiation factor

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased length of anterior-posterior axis (4 sources), abnormal head morphology (3 sources), wholly dorsalized embryo (3 sources), abnormal gastrulation (2 sources), abnormal axis elongation (1 source), abnormal proctodeum morphology (1 source), abnormal tadpole morphology (1 source), abnormal tail bud morphology (1 source), abnormal tail morphology (1 source), abnormal ventral trunk morphology (1 source), abnormally delayed closure of blastopore (1 source), absent head (1 source), absent tail (1 source), decreased length of tail (1 source), decreased size of the whole organism (1 source), tail abnormally curved dorsally (1 source), wholly ventralized embryo (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

decreased length of anterior-posterior axis (4 sources), abnormal head morphology (3 sources), wholly dorsalized embryo (3 sources), abnormal gastrulation (2 sources), abnormal axis elongation (1 source), abnormal proctodeum morphology (1 source), abnormal tadpole morphology (1 source), abnormal tail bud morphology (1 source), abnormal tail morphology (1 source), abnormal ventral trunk morphology (1 source), abnormally delayed closure of blastopore (1 source), absent head (1 source), absent tail (1 source), decreased length of tail (1 source), decreased size of the whole organism (1 source), tail abnormally curved dorsally (1 source), wholly ventralized embryo (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: nodal assayed (11 sources)
Computed annotations: nodal assayed (9 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + nodal1 MO (2 sources), Xtr Wt + nodal3.1 MO (2 sources), Xla Wt + nodal (1 source), Xla Wt + nodal1 (1 source), Xla Wt + nodal1 (1 source), Xla Wt + nodal1 + animal cap explant (1 source), Xla Wt + nodal1 + ctnnb1 MO (1 source), Xla Wt + nodal1 + sia1 MO + sia2 MO (1 source), Xla Wt + nodal1 + tle4 (1 source), Xla Wt + nodal1 + dntcf3 (1 source), Xla Wt + nodal2 (1 source), Xla Wt + nodal2 + animal cap explant (1 source), Xla Wt + nodal2 + animal cap explant (1 source), Xla Wt + nodal5 (1 source), Xla Wt + wnt8a + nodal2 + animal cap explant (1 source), Xtr Wt + nodal3.1 MO (1 source)

Experiments (Reagents)

These are short form descriptions of experiments using reagents targeting the gene of interest.

Xtr Wt + nodal1 MO (2 sources), Xtr Wt + nodal3.1 MO (2 sources), Xla Wt + nodal (1 source), Xla Wt + nodal1 (1 source), Xla Wt + nodal1 (1 source), Xla Wt + nodal1 + animal cap explant (1 source), Xla Wt + nodal1 + ctnnb1 MO (1 source), Xla Wt + nodal1 + sia1 MO + sia2 MO (1 source), Xla Wt + nodal1 + tle4 (1 source), Xla Wt + nodal1 + dntcf3 (1 source), Xla Wt + nodal2 (1 source), Xla Wt + nodal2 + animal cap explant (1 source), Xla Wt + nodal2 + animal cap explant (1 source), Xla Wt + nodal5 (1 source), Xla Wt + wnt8a + nodal2 + animal cap explant (1 source), Xtr Wt + nodal3.1 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (41 sources): Abdominal situs inversus, Abnormality of cardiovascular system morphology, Abnormality of the respiratory system, Agenesis of corpus callosum, Ambiguous genitalia, Anteverted nares, Asthma, Atrial septal defect, Choanal atresia, Cleft palate, Cyclopia, Dextrocardia, Duodenal atresia, EMG: myopathic abnormalities, Hemangioma, Holoprosencephaly, Hypoplasia of penis, Hypotelorism, Hypothyroidism, Intellectual disability, Intrauterine growth retardation, Iris coloboma, Maternal diabetes, Microcephaly, Midnasal stenosis, Narrow nasal bridge, Oral cleft, Panhypopituitarism, Premature birth, Renal agenesis, Scoliosis, Seizure, Short nose, Short philtrum, Short stature, Solitary median maxillary central incisor, Strabismus, Tented upper lip vermilion, Tetralogy of Fallot, Transposition of the great arteries, Ventricular septal defect [+]
Mouse (96 sources): abnormal anterior visceral endoderm morphology, abnormal brain development, abnormal craniofacial development, abnormal developmental patterning, abnormal digestive system development, abnormal direction of heart looping, abnormal distal visceral endoderm morphology, abnormal ectoderm development, abnormal embryo turning, abnormal embryonic neuroepithelium morphology, abnormal embryonic tissue morphology, abnormal extraembryonic ectoderm morphology, abnormal extraembryonic mesoderm development, abnormal extraembryonic tissue morphology, abnormal foregut morphology, abnormal gastrulation, abnormal gastrulation movements, abnormal germ layer development, abnormal grip strength, abnormal head development, abnormal heart apex morphology, abnormal heart development, abnormal heart looping, abnormal heart position or orientation, abnormal hindgut morphology, abnormal lateral plate mesoderm morphology, abnormal left-right axis patterning, abnormal mesendoderm development, abnormal mesoderm development, abnormal neural fold formation, abnormal parietal yolk sac morphology, abnormal prechordal plate morphology, abnormal primitive node morphology, abnormal primitive streak formation, abnormal primitive streak morphology, abnormal proximal-distal axis patterning, abnormal rostral-caudal axis patterning, abnormal spongiotrophoblast layer morphology, abnormal stomach position or orientation, abnormal visceral endoderm morphology, abnormal visceral yolk sac morphology, absent allantois, absent amnion, absent amniotic folds, absent floor plate, absent forebrain, absent foregut, absent head fold, absent heart tube, absent mesoderm, absent notochord, absent placental labyrinth, absent prechordal plate, absent primitive node, absent somites, absent visceral yolk sac, aortic hypertrophy, decreased body size, decreased embryo size, decreased embryonic neuroepithelial cell proliferation, delayed heart development, embryo phenotype, embryonic growth arrest, embryonic lethality between implantation and somite formation, complete penetrance, embryonic lethality between somite formation and embryo turning, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, embryonic lethality prior to tooth bud stage, embryonic lethality, incomplete penetrance, embryonic-extraembryonic boundary constriction, enlarged pericardium, failure of primitive streak formation, fused somites, increased grip strength, increased spongiotrophoblast size, increased trophoblast giant cell number, neonatal lethality, complete penetrance, no abnormal phenotype detected, pale liver, pericardial edema, perinatal lethality, complete penetrance, premature death, prenatal lethality, complete penetrance, prenatal lethality, incomplete penetrance, preweaning lethality, complete penetrance, right pulmonary isomerism, right-sided isomerism, rostral body truncation, situs ambiguus, small ectoplacental cone, small liver, small spleen, thin myocardium compact layer, thin placenta labyrinth, trabecula carnea hypoplasia, truncated foregut, truncated notochord [+]
View all ortholog results at Monarch