| Monarch Ortholog Phenotypes
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Human (41 sources):
Abnormality of circulating adrenocorticotropin level,
Accelerated skeletal maturation,
Adrenal insufficiency,
Anorexia,
Azoospermia,
Chronic fatigue,
Coma,
Congenital hypothyroidism,
Constipation,
Cryptorchidism,
Decreased circulating cortisol level,
Decreased circulating dehydroepiandrosterone concentration,
Diarrhea,
Episodic abdominal pain,
Failure to thrive,
Generalized hyperpigmentation,
Hyperkalemia,
Hypernatriuria,
Hyperpigmentation of the skin,
Hypertrophic cardiomyopathy,
Hypoglycemic coma,
Hypoglycemic seizures,
Hyponatremia,
Hypotension,
Impaired cortisol response to insulin stimulation test,
Increased circulating ACTH level,
Intellectual disability,
Ketotic hypoglycemia,
Leydig cell neoplasia,
Precocious puberty,
Recurrent hypoglycemia,
Recurrent infections,
Recurrent urinary tract infections,
Renal salt wasting,
Seizure,
Tall stature,
Testicular adrenal rest tumor,
Tetraplegia,
Vomiting,
Weight loss,
obsolete Decreased circulating aldosterone level
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Mouse (12 sources):
abnormal adrenal gland capsule morphology,
abnormal adrenal gland zona fasciculata morphology,
abnormal gluconeogenesis,
adrenal cortical hyperplasia,
decreased brown fat lipid droplet number,
decreased circulating adrenaline level,
decreased percent body fat/body weight,
increased anxiety-related response,
increased spleen weight,
increased susceptibility to pharmacologically induced seizures,
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.