ihh Phenotypes

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Phenotypes

Gene Literature (40)

Nucleotides (86)

Interactants (563)

XB-GENEPAGE-484186

Gene Symbol: ihh Gene Name: indian hedgehog

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased width of the neural plate (2 sources), decreased size of the Meckel's cartilage (1 source), decreased size of the ceratobranchial I (1 source), decreased size of the ceratobranchial II (1 source), decreased size of the ceratobranchial III (1 source), decreased size of the ceratobranchial IV (1 source), decreased size of the ceratohyal (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: ihh manipulated (20 sources), ihh assayed (5 sources)
Computed annotations: ihh assayed (5 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + ihh (5 sources), Xla Wt + ihh MO (5 sources), Xla Wt + ihhdel_591-819 (4 sources), Xla Wt + dnihhdel_84-582 (4 sources), Xla Wt + ihh MO (2 sources), Xla Wt + alpha-3000:ihh (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (68 sources): Abnormal femoral neck morphology, Absent distal interphalangeal creases, Aplasia/Hypoplasia of the middle phalanges of the hand, Aplasia/Hypoplasia of the middle phalanges of the toes, Brachydactyly, Broad metacarpal epiphyses, Broad metacarpals, Broad nail, Broad palm, Clinodactyly of the 5th finger, Cone-shaped capital femoral epiphysis, Cone-shaped epiphyses of the phalanges of the hand, Cone-shaped epiphysis, Cone-shaped epiphysis of the 1st metacarpal, Cone-shaped metacarpal epiphyses, Coxa vara, Cupped ribs, Delayed ossification of carpal bones, Delayed skeletal maturation, Disproportionate short stature, Disproportionate short-limb short stature, Distal symphalangism of hands, Dysplasia of the femoral head, Enlargement of the distal femoral epiphysis, Fibular overgrowth, Flared iliac wing, Flattened metatarsal heads, Genu varum, Hyperlordosis, Hypoplasia of the radius, Hypoplasia of the ulna, Hypoplastic iliac wing, Lumbar hyperlordosis, Macrocephaly, Micromelia, Narrow chest, Ovoid vertebral bodies, Pectus carinatum, Pectus excavatum, Proportionate shortening of all digits, Radial deviation of the 2nd finger, Radial deviation of the 3rd finger, Radial deviation of the 4th finger, Relative macrocephaly, Scoliosis, Short distal phalanx of finger, Short femoral neck, Short femur, Short foot, Short hallux, Short humerus, Short metacarpal, Short middle phalanx of finger, Short palm, Short proximal phalanx of finger, Short proximal phalanx of hallux, Short proximal phalanx of thumb, Short ribs, Short stature, Short thorax, Short thumb, Short tibia, Skeletal dysplasia, Slender metacarpals, Small finger, Small nail, Talipes equinovarus, Thin proximal phalanges with broad epiphyses of the hand [+]
Mouse (39 sources): abnormal basicranium morphology, abnormal bone mineralization, abnormal cartilage development, abnormal chondrocyte differentiation, abnormal digestive organ placement, abnormal digestive system morphology, abnormal digit development, abnormal duodenum morphology, abnormal forelimb morphology, abnormal humerus morphology, abnormal long bone epiphyseal plate proliferative zone, abnormal phalanx morphology, abnormal skeleton development, abnormal smooth muscle morphology, abnormal sternum morphology, abnormal synchondrosis, abnormal visceral yolk sac morphology, abnormal vitelline vasculature morphology, absent compact bone, absent enteric neurons, chondrodystrophy, decreased chondrocyte proliferation, decreased fetal size, decreased long bone epiphyseal plate size, decreased osteoblast cell number, decreased width of hypertrophic chondrocyte zone, delayed endochondral bone ossification, digestive/alimentary phenotype, disorganized long bone epiphyseal plate, disproportionate dwarf, domed cranium, embryonic lethality during organogenesis, incomplete penetrance, megacolon, neonatal lethality, complete penetrance, postnatal lethality, short mandible, short scapula, short tail, vision/eye phenotype [+]
View all ortholog results at Monarch