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Summary Expression Phenotypes Gene Literature (231) GO Terms (11) Nucleotides (362) Proteins (43) Interactants (1855) Wiki

tp53     tumor protein p53

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal head morphology (2 sources), abnormally neoplastic somite (2 sources), decreased length of anterior-posterior axis (2 sources), abnormal axis elongation (1 source), abnormal brain morphology (1 source), abnormal gastrulation (1 source), abnormal pancreas morphology (1 source), abnormal somite morphology (1 source), abnormal tail bud morphology (1 source), abnormal tail morphology (1 source), abnormally delayed closure of blastopore (1 source), abnormally increased number of melanoblast (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: tp53 assayed (1 source)
Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
glioblastoma (2AP sources), choroid plexus cancer (1AP source), medulloblastoma (1AP source), pancreatic cancer (1AP source), pineoblastoma (1AP source)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + tp53 (4 sources), Xtr Wt + tp53 MO (3 sources), Xtr Wt + rb1 CRISPR + rbl1 CRISPR + tp53 CRISPR (1 source), Xtr Wt + rb1 CRISPR + rbl1 CRISPR + tp53 CRISPR + pten CRISPR (1 source), Xtr.tp53em_del1/em_del2_Vlemx + rb1 CRISPR + rbl1 CRISPR (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (107 sources): Abdominal distention, Abdominal pain, Abnormal lactate dehydrogenase level, Abnormal nervous system morphology, Abnormal rectum morphology, Abnormality of metabolism/homeostasis, Abnormality of the femoral metaphysis, Abnormality of the hepatic vasculature, Abnormality of the liver, Abnormality of the metaphysis, [+]
Mouse (215 sources): abnormal DNA replication, abnormal Peyer's patch morphology, abnormal abdominal lymph node morphology, abnormal apoptosis, abnormal atrioventricular cushion morphology, abnormal cardiac outflow tract development, abnormal cell cycle checkpoint function, abnormal cell death, abnormal cell migration, abnormal cell proliferation, [+]

View all ortholog results at Monarch