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Summary Expression Phenotypes Gene Literature (580) GO Terms (106) Nucleotides (552) Proteins (48) Interactants (2509) Wiki
XB-GENEPAGE-484552

sox2     SRY-box 2

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal esophagus morphology (1 source), abnormal trachea morphology (1 source), abnormal tracheoesophageal septum (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: sox2 assayed (111 sources)
Computed annotations: sox2 assayed (16 sources)
Diseases
Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
esophageal atresia (1AP source), esophageal atresia/tracheoesophageal fistula (1AP source)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + sox2 CRISPR (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (72 sources): 11 pairs of ribs, Abnormal cardiovascular system morphology, Abnormality of the hypothalamus-pituitary axis, Abnormal vertebral morphology, Absent septum pellucidum, Agenesis of corpus callosum, Anophthalmia, Anosmia, Anterior pituitary hypoplasia, Aplasia/Hypoplasia of the cerebellum, [+]
Mouse (94 sources): abnormal adenohypophysis development, abnormal auchene hair morphology, abnormal awl hair morphology, abnormal bronchiole epithelium morphology, abnormal cerebral cortex morphology, abnormal cochlear hair cell morphology, abnormal dentate gyrus morphology, abnormal Ebner's gland morphology, abnormal ectoderm development, abnormal ependyma morphology, [+]

View all ortholog results at Monarch