| Monarch Ortholog Phenotypes
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Human (7 sources):
Edema,
Focal segmental glomerulosclerosis,
Hyperlipidemia,
Hypoalbuminemia,
Nephrotic syndrome,
Proteinuria,
Stage 5 chronic kidney disease
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Mouse (39 sources):
abnormal glomerular capillary endothelium morphology,
abnormal glomerular capillary morphology,
abnormal glomerular endothelium fenestra morphology,
abnormal kidney arterial blood vessel morphology,
abnormal kidney morphology,
abnormal peritubular capillary morphology,
abnormal podocyte foot process morphology,
abnormal podocyte morphology,
abnormal proximal convoluted tubule morphology,
abnormal renal glomerular capsule morphology,
abnormal renal glomerulus basement membrane morphology,
abnormal renal glomerulus morphology,
abnormal renal tubule epithelium morphology,
abnormal renal tubule morphology,
absent podocyte slit diaphragm,
cortical renal glomerulopathies,
decreased body size,
decreased podocyte number,
dilated glomerular capillary,
dilated proximal convoluted tubule,
dilated renal tubules,
fused podocyte foot processes,
glomerular crescent,
increased circulating creatinine level,
increased mesangial cell number,
increased renal glomerulus basement membrane thickness,
increased systemic arterial blood pressure,
increased systemic arterial systolic blood pressure,
increased urine creatinine level,
kidney hemorrhage,
perinatal lethality, incomplete penetrance,
podocyte foot process effacement,
podocyte hypertrophy,
podocyte microvillus transformation,
postnatal lethality, complete penetrance,
premature death,
renal cast,
renal glomerulus hypertrophy,
renal/urinary system phenotype
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.