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Summary Expression Phenotypes Gene Literature (529) GO Terms (13) Nucleotides (304) Proteins (56) Interactants (2508) Wiki
XB-GENEPAGE-485219

otx2     orthodenticle homeobox 2

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal gastrulation (7 sources), decreased size of the notochord (2 sources), abnormal anterior-posterior axis, curved ventral (1 source), abnormal convergent extension (1 source), abnormal embryo morphology (1 source), abnormal head morphology (1 source), abnormal incomplete closing of the blastopore (1 source), abnormal neural tube closure (1 source), abnormal tail morphology (1 source), abnormally delayed closure of blastopore (1 source), decreased length of trunk (1 source), decreased size of the head (1 source), decreased size of the tail (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: otx2 manipulated (10 sources), otx2 assayed (58 sources)
Computed annotations: otx2 assayed (42 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + otx2 (12 sources), Xla Wt + lhx1 MO + otx2 MO (2 sources), Xla Wt + lhx1 + otx2 (1 source), Xla Wt + lhx1 + otx2 + sia1 MO + sia2 MO (1 source), Xla Wt + lhx1 MO + otx2 MO (1 source), Xla Wt + otx2 MO (1 source), Xla Wt + otx2 MO (1 source), Xla Wt + otx2 MO (1 source), Xla Wt + otx2-VP16 (1 source), Xtr Wt + irx3 + otx2 + animal cap explant (0 sources), Xtr Wt + otx2 + animal cap explant (0 sources)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (99 sources): Abnormal cranial nerve morphology, Abnormal digit morphology, Abnormal prolactin level, Abnormality of cardiovascular system morphology, Abnormality of secondary sexual hair, Abnormality of the hypothalamus-pituitary axis, Abnormality of the orbital region, Abnormality of the outer ear, Absence of secondary sex characteristics, Absent nares, [+]
Mouse (154 sources): abnormal Meckel's cartilage morphology, abnormal adenohypophysis morphology, abnormal alisphenoid bone morphology, abnormal allantois morphology, abnormal amnion morphology, abnormal anterior head development, abnormal axial mesoderm morphology, abnormal basisphenoid bone morphology, abnormal brain development, abnormal cephalic neural fold morphology, [+]

View all ortholog results at Monarch