| Monarch Ortholog Phenotypes
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Human (12 sources):
Abnormality of neutrophils,
Congestive heart failure,
Dilated cardiomyopathy,
Elevated circulating creatine kinase concentration,
EMG abnormality,
Hypertrophic cardiomyopathy,
Lipoatrophy,
Mitral regurgitation,
Myopathy,
Palmoplantar keratoderma,
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Mouse (36 sources):
abnormal atrial thrombosis,
abnormal bronchiole morphology,
abnormal calcium ion homeostasis,
abnormal cardiac muscle contractility,
abnormal cardiac muscle relaxation,
abnormal diastolic filling velocity,
abnormal heart ventricle pressure,
abnormal myocardial fiber morphology,
abnormal myocardial fiber physiology,
abnormal response to exercise,
cardiac fibrosis,
cardiac hypertrophy,
cardiac interstitial fibrosis,
decreased cardiac muscle contractility,
decreased cardiac muscle relaxation,
decreased cardiac output,
decreased embryo size,
decreased left ventricle diastolic pressure,
decreased left ventricle systolic pressure,
decreased physiological sensitivity to xenobiotic,
decreased ventricle muscle contractility,
dilated heart ventricle,
disorganized myocardium,
embryonic lethality, complete penetrance,
embryonic lethality during organogenesis, complete penetrance,
enlarged heart atrium,
enlarged myocardial fiber,
increased cardiac muscle contractility,
increased heart weight,
increased left ventricle diastolic pressure,
increased lung weight,
increased prepulse inhibition,
increased startle reflex,
myocardium hypertrophy,
no abnormal phenotype detected,
premature death
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.