Monarch Ortholog Phenotypes
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Human (66 sources):
Abnormal cardiac septum morphology,
Abnormal drinking behavior,
Abnormal eating behavior,
Abnormal facial shape,
Abnormal pulmonary interstitial morphology,
Abnormal sella turcica morphology,
Abnormality of movement,
Abnormality of the nervous system,
Abnormality of the respiratory system,
Abnormality of the thyroid gland,
Agenesis of corpus callosum,
Anxiety,
Apraxia,
Asthma,
Ataxia,
Atrial septal defect,
Cavum septum pellucidum,
Chorea,
Choreoathetosis,
Clumsiness,
Compensated hypothyroidism,
Compulsive behaviors,
Congenital hypothyroidism,
Difficulty walking,
Dysarthria,
Dystonia,
Elevated circulating thyroid-stimulating hormone concentration,
Failure to thrive,
Falls,
Gait disturbance,
Generalized hypotonia,
Global developmental delay,
Growth delay,
Hyperactivity,
Hypodontia,
Hypoparathyroidism,
Hypospadias,
Hypotonia,
Incoordination,
Infantile muscular hypotonia,
Intellectual disability, mild,
Intention tremor,
Involuntary movements,
Megacystis,
Microcephaly,
Motor delay,
Myoclonus,
Neonatal respiratory distress,
Patent foramen ovale,
Pulmonary arterial hypertension,
Pulmonary fibrosis,
Recurrent pneumonia,
Recurrent respiratory infections,
Respiratory distress,
Respiratory insufficiency,
Schizophrenia,
Sensorineural hearing impairment,
Short attention span,
Short stature,
Sleep disturbance,
Thyroid dysgenesis,
Thyroid hemiagenesis,
Unexplained fevers,
Ventricular septal defect,
Vesicoureteral reflux,
Webbed neck
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Mouse (55 sources):
abnormal Rathke's pouch apoptosis,
abnormal Rathke's pouch development,
abnormal adenohypophysis development,
abnormal adrenal cortex morphology,
abnormal branching involved in lung morphogenesis,
abnormal bronchus epithelium morphology,
abnormal bronchus morphology,
abnormal diencephalon morphology,
abnormal foregut morphology,
abnormal lung development,
abnormal lung epithelium morphology,
abnormal lung saccule morphology,
abnormal lung vasculature morphology,
abnormal mesenchymal cell differentiation involved in lung development,
abnormal ovulation,
abnormal pituitary gland development,
abnormal pleural cavity morphology,
abnormal pulmonary acinus morphology,
abnormal pulmonary alveolar parenchyma morphology,
abnormal pulmonary alveolus epithelial cell morphology,
abnormal testes secretion,
abnormal thoracic cavity morphology,
abnormal thyroid follicle morphology,
abnormal thyroid gland development,
abnormal tracheal cartilage morphology,
abnormal type II pneumocyte morphology,
abnormal ventromedial hypothalamic nucleus morphology,
absent infundibular recess of third ventricle,
absent pituitary infundibular stalk,
absent type II pneumocytes,
behavior/neurological phenotype,
decreased exploration in new environment,
decreased fetal weight,
decreased lung weight,
decreased surfactant secretion,
decreased testis weight,
decreased tracheal cartilage ring number,
decreased ventromedial hypothalamic nucleus size,
delayed estrous cycle,
dilated respiratory conducting tube,
early reproductive senescence,
endocrine/exocrine gland phenotype,
enhanced coordination,
impaired branching involved in bronchus morphogenesis,
impaired branching involved in respiratory bronchiole morphogenesis,
increased adenoma incidence,
increased anxiety-related response,
increased circulating thyroid-stimulating hormone level,
neonatal lethality, complete penetrance,
nervous system phenotype,
no abnormal phenotype detected,
prolonged estrous cycle,
reduced female fertility,
reproductive system phenotype,
small thyroid gland
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View all ortholog results at Monarch
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