c3 Phenotypes

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Phenotypes

Gene Literature (11)

Nucleotides (1050)

Interactants (242)

XB-GENEPAGE-486273

Gene Symbol: c3 Gene Name: complement C3

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal superficial layer of neurectoderm (2 sources), abnormally increased number of cell (2 sources)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: c3 assayed (18 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + c3 MO (1 source), Xla Wt + C3a Antibody (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (6 sources): Decreased serum complement C3, Membranoproliferative glomerulonephritis, Nephrotic syndrome, Recurrent bacterial infections, Renal insufficiency, Systemic lupus erythematosus
Mouse (67 sources): abnormal blastocyst morphology, abnormal blood coagulation, abnormal blood homeostasis, abnormal c-wave shape, abnormal cell-mediated immunity, abnormal circulating sodium level, abnormal dendritic spine morphology, abnormal enzyme/coenzyme level, abnormal exploration in a new environment, abnormal eye electrophysiology, abnormal hippocampus CA3 region morphology, abnormal humoral immune response, abnormal induced morbidity/mortality, abnormal intestinal lipid absorption, abnormal lipid homeostasis, abnormal motor learning, abnormal peripheral nervous system regeneration, abnormal retina horizontal cell morphology, abnormal retina rod bipolar cell morphology, abnormal spatial working memory, abnormal spleen germinal center morphology, abnormal synaptic plasticity, abnormal synaptic vesicle number, abnormal tumor necrosis factor level, decreased anxiety-related response, decreased b-wave amplitude, decreased cerebral infarct size, decreased circulating alanine transaminase level, decreased circulating free fatty acids level, decreased circulating glucose level, decreased circulating interleukin-6 level, decreased circulating tumor necrosis factor level, decreased exploration in new environment, decreased fetal weight, decreased hepatocyte proliferation, decreased mast cell number, decreased osteoclast cell number, decreased placental labyrinth size, decreased spleen germinal center number, decreased spleen germinal center size, decreased spongiotrophoblast size, decreased susceptibility to Coronaviridae infection, decreased susceptibility to autoimmune hemolytic anemia, decreased susceptibility to hepatic steatosis, decreased susceptibility to induced arthritis, decreased susceptibility to injury, decreased urine albumin level, decreased vascular permeability, decreased white adipose tissue amount, enhanced contextual conditioning behavior, enhanced long term potentiation, enhanced paired-pulse facilitation, enhanced spatial learning, focal hepatic necrosis, immune system phenotype, impaired complement alternative pathway, impaired embryo implantation, impaired liver regeneration, increased brown adipose tissue amount, increased circulating alanine transaminase level, increased neuron number, increased sensitivity to induced morbidity/mortality, increased susceptibility to bacterial infection induced morbidity/mortality, increased triglyceride level, no abnormal phenotype detected, prolonged estrous cycle, vision/eye phenotype [+]
View all ortholog results at Monarch