Epistaxis, Fatigue, Fever, Gastrointestinal hemorrhage, Gingival bleeding, Hearing impairment, Hepatomegaly, Hypercoagulability, Immunodeficiency, Impaired lymphocyte transformation with phytohemagglutinin, Leukemia, Lymphadenopathy, Lymphoma, Malabsorption, Memory impairment, Migraine, Monoclonal immunoglobulin M proteinemia, Multifocal epileptiform discharges, Normocytic anemia, Pallor, Pedal edema, Periorbital edema, Peripheral neuropathy, Pleural effusion, Polyclonal elevation of IgM, Polyneuropathy, Proptosis, Pulmonary infiltrates, Purpura, Recurrent bacterial skin infections, Recurrent infections, Reduced consciousness/confusion, Renal insufficiency, Respiratory insufficiency, Retinal hemorrhage, Splenomegaly, Stroke, Urticaria, Vasculitis, Vertigo

abnormal cytokine level, abnormal dendritic cell antigen presentation, abnormal dendritic cell differentiation, abnormal dendritic cell physiology, abnormal enterocyte morphology, abnormal enterocyte physiology, abnormal gut flora balance, abnormal innate immunity, abnormal interferon level, abnormal macrophage physiology, abnormal memory T cell physiology, abnormal microglial cell physiology, abnormal neuron differentiation, abnormal pancreatic beta cell morphology, abnormal pancreatic beta cell physiology, abnormal parametrial fat pad morphology, abnormal response to infection, abnormal retina progenitor cell morphology, abnormal susceptibility to bacterial infection, abnormal susceptibility to hearing loss, abnormal tumor necrosis factor level, bronchiolitis, decreased B cell proliferation, decreased CXCL10 level, decreased IgG1 level, decreased IgG2b level, decreased IgG2c level, decreased IgG3 level, decreased body length, decreased circulating alanine transaminase level, decreased circulating aspartate transaminase level, decreased circulating interleukin-10 level, decreased circulating interleukin-12b level, decreased circulating interleukin-6 level, decreased circulating tumor necrosis factor level, decreased effector memory CD4-positive, alpha-beta T cell number, decreased epididymal fat pad weight, decreased fat cell size, decreased food intake, decreased incidence of tumors by chemical induction, decreased interferon-alpha secretion, decreased interferon-gamma secretion, decreased interleukin-1 beta secretion, decreased interleukin-10 secretion, decreased interleukin-12 secretion, decreased interleukin-12b secretion, decreased interleukin-6 secretion, decreased liver tumor incidence, decreased locomotor activity, decreased macrophage cell number, decreased mean corpuscular volume, decreased pancreatic beta cell mass, decreased susceptibility to diet-induced obesity, decreased susceptibility to experimental autoimmune encephalomyelitis, decreased susceptibility to induced arthritis, decreased susceptibility to kidney reperfusion injury, decreased susceptibility to parasitic infection, decreased tumor necrosis factor secretion, digestive/alimentary phenotype, hematopoietic system phenotype, immune system phenotype, increased IgG1 level, increased apoptosis, increased circulating alanine transaminase level, increased circulating aspartate transaminase level, increased circulating tumor necrosis factor level, increased dendritic cell number, increased energy expenditure, increased insulin sensitivity, increased physiological sensitivity to xenobiotic, increased susceptibility to Coronaviridae infection, increased susceptibility to Coronaviridae infection induced morbidity/mortality, increased susceptibility to Herpesvirales infection, increased susceptibility to Picornaviridae infection, increased susceptibility to induced colitis, increased susceptibility to injury, reproductive system phenotype, small pancreatic islets