irx1 Phenotypes

Phenotypes

XB-GENEPAGE-486816

Gene Symbol: irx1 Gene Name: iroquois homeobox 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal incomplete closing of the blastopore (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: irx1 manipulated (29 sources), irx1 assayed (36 sources)
Computed annotations: irx1 assayed (26 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + irx1 (18 sources), Xla Wt + irx1-VP16 (4 sources), Xla Wt + irx1 + Six1 MO (3 sources), Xla Wt + irx1 (1 source), Xla Wt + irx1 (1 source), Xla Wt + irx1 (1 source), Xla Wt + Tg(irx1-EnR-hGR) + ChX + Dex (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (24 sources): abnormal abdominal wall morphology, abnormal ameloblast differentiation, abnormal craniofacial morphology, abnormal cranium morphology, abnormal dental epithelium morphology, abnormal embryo size, abnormal grip strength, abnormal lower incisor morphology, abnormal lung development, abnormal odontoblast morphology, abnormal outer dental epithelium morphology, abnormal respiratory mechanics, abnormal stratum intermedium morphology, abnormal tooth development, absent gastric milk in neonates, decreased grip strength, decreased locomotor activity, decreased surfactant secretion, growth retardation of incisors, increased thigmotaxis, neonatal lethality, complete penetrance, preweaning lethality, complete penetrance, short lower incisors, small lung [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (24 sources): abnormal abdominal wall morphology, abnormal ameloblast differentiation, abnormal craniofacial morphology, abnormal cranium morphology, abnormal dental epithelium morphology, abnormal embryo size, abnormal grip strength, abnormal lower incisor morphology, abnormal lung development, abnormal odontoblast morphology, [+]