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Summary Expression Phenotypes Gene Literature (527) GO Terms (39) Nucleotides (1096) Proteins (52) Interactants (1973) Wiki
XB-GENEPAGE-487199

ctnnb1     catenin beta 1

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
duplicated anterior-posterior axis (23 sources), abnormal determination of left/right symmetry (3 sources), abnormal development of lung (3 sources), abnormal Wnt signaling pathway (2 sources), abnormal axis specification (2 sources), abnormal head morphology (2 sources), abnormal nodal signaling pathway (2 sources), abnormally ventralized embryo (2 sources), duplicated anatomical axis (2 sources), duplicated head (2 sources), duplicated trunk (2 sources), wholly anterioralized embryo (2 sources), abnormal anterior-posterior axis, curved ventral (1 source), abnormal bending of anterior-posterior axis (1 source), abnormal detection of nodal flow (1 source), abnormal heart looping (1 source), abnormally localised lung bud (1 source), abnormally localised pancreas (1 source), absent dorsal pancreatic bud (1 source), absent head (1 source), absent liver (1 source), absent ventral pancreatic bud (1 source), decreased size of the foregut (1 source), decreased size of the tail bud (1 source), increased size of the cement gland (1 source), increased size of the head (1 source), increased size of the liver primordium (1 source), increased size of the lung bud (1 source), increased size of the neural tube (1 source), wholly ventralized embryo (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: ctnnb1 manipulated (63 sources), ctnnb1 assayed (17 sources)
Computed annotations: ctnnb1 manipulated (15 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + ctnnb1 MO (10 sources), Xla Wt + ctnnb1 (8 sources), Xla Wt + ctnnb1tm1 (7 sources), Xla Wt + ctnnb1 (5 sources), Xla Wt + hhex + ctnnb1 (4 sources), Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + DEX (4 sources), Wt + ctnnb1 MO (3 sources), WT + ctnnb1 (2 sources), Xla Wt + ctnnb1 MO (2 sources), Xla Wt + ctnnb1 MO (2 sources), Xla Wt + ctnnb1 MO (2 sources), Xla Wt + ctnnb1 MO (2 sources), Xla Wt + ctnnb1tm1 (2 sources), Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + DEX (2 sources), Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + DEX (2 sources), Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + DEX (2 sources), Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + DEX + PD173074 (2 sources), Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + wnt2 MO + DEX (2 sources), Xla.pigmented(Nasco) + ctnnb1 MO (2 sources), WE + ctnnb1 MO + LDN193189 (1 source), WE + ctnnb1 MO + SB431542 (1 source), Xla Wt + cer1del + ctnnb1tm1 (1 source), Xla Wt + ctnnb1 (1 source), Xla Wt + ctnnb1 (1 source), Xla Wt + ctnnb1 (1 source), Xla Wt + ctnnb1 (1 source), Xla Wt + ctnnb1 (1 source), Xla Wt + ctnnb1 (1 source), Xla Wt + ctnnb1 (1 source), Xla Wt + ctnnb1 + animal cap explant (1 source), Xla Wt + ctnnb1 + animal cap explant (1 source), Xla Wt + ctnnb1 + animal cap explant (1 source), Xla Wt + ctnnb1 + ccdc88c MO (1 source), Xla Wt + ctnnb1 + dnah9 MO (1 source), Xla Wt + ctnnb1 + pias4 (1 source), Xla Wt + ctnnb1 + pias4 (1 source), Xla Wt + ctnnb1 + rnf220.1 (1 source), Xla Wt + ctnnb1 + sox17b.2 (1 source), Xla Wt + ctnnb1 MO (1 source), Xla Wt + ctnnb1 MO (1 source), Xla Wt + ctnnb1 MO (1 source), Xla Wt + ctnnb1 MO (1 source), Xla Wt + ctnnb1 MO (1 source), Xla Wt + ctnnb1-GFP (1 source), Xla Wt + ctnnb1-GFP + sox17b.1 + animal cap explant (1 source), Xla Wt + ctnnb1-GFP + sox17b.1 + animal cap explant (1 source), Xla Wt + ctnnb1del (1 source), Xla Wt + ctnnb1del + ctnnb1 MO (1 source), Xla Wt + ctnnb1del + sox17b.1 + ctnnb1 MO + animal cap explant (1 source), Xla Wt + ctnnb1tm1 (1 source), Xla Wt + ctnnb1tm1 + animal cap explant (1 source), Xla Wt + ctnnb1tm1 + endoderm explant (1 source), Xla Wt + ctnnb1tm1 + hbp1 (1 source), Xla Wt + ctnnb1tm1 + sox17b.2 (1 source), Xla Wt + ctnnb1tm1 + sox17b.2 (1 source), Xla Wt + ctnnb1tm1 + sox17b.2 + animal cap explant (1 source), Xla Wt + HA-sox17bdel945_1119 + ctnnb1tm1 (1 source), Xla Wt + HA-sox17bdel_168_1119 + ctnnb1tm1 (1 source), Xla Wt + HA-sox17bdel_450_1119 + ctnnb1tm1 (1 source), Xla Wt + HA-sox17bdel_810_1119 + ctnnb1tm1 (1 source), Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + DEX (1 source), Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + DEX (1 source), Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + DEX (1 source), Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + DEX (1 source), Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + DEX (1 source), Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + DEX (1 source), Xla Wt + Mmu.lef1-Mmu.ctnnb1-GR + fzd7 MO + DEX (1 source), Xla Wt + nodal1 + ctnnb1 MO (1 source), Xla Wt + sia1 + ctnnb1 MO (1 source), Xtr Wt + ctnnb1 MO (1 source), Xtr Wt + ctnnb1 MO + LDN-193189 + SB431542 (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (189 sources): Abdominal distention, Abdominal pain, Abnormal brain FDG positron emission tomography, Abnormal cranial nerve morphology, Abnormal facial shape, Abnormal hypothalamus morphology, Abnormal nasal bone morphology, Abnormal rectum morphology, Abnormal temper tantrums, Abnormal visual field test, [+]
Mouse (275 sources): abnormal Meckel's cartilage morphology, abnormal Mullerian duct morphology, abnormal adenohypophysis morphology, abnormal anterior head development, abnormal apical ectodermal ridge morphology, abnormal axial mesoderm morphology, abnormal blood-brain barrier function, abnormal bone mineralization, abnormal brain development, abnormal cartilage development, [+]

View all ortholog results at Monarch