Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.

Summary Expression Phenotypes Gene Literature (523) GO Terms (6) Nucleotides (111) Proteins (42) Interactants (1733) Wiki
XB-GENEPAGE-487723

nog     noggin

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal head morphology (3 sources), abnormal axis specification (2 sources), abnormal development of head (2 sources), abnormal eye morphology (2 sources), duplicated anterior-posterior axis (2 sources), increased size of the cement gland (2 sources), wholly ventralized embryo (2 sources), abnormal gastrulation (1 source), abnormally decreased number of bipolar neuron in the retinal inner plexiform layer (1 source), abnormally increased number of eye (1 source), abnormally laterally curved whole organism (1 source), abnormally medially mislocalised eye (1 source), abnormally posterioralized embryo (1 source), abnormally ventralized embryo (1 source), absent barbel (1 source), decreased length of anterior-posterior axis (1 source), decreased length of tail (1 source), decreased size of the cement gland (1 source), decreased size of the eye (1 source), decreased size of the tail (1 source), duplicated head (1 source), duplicated trunk (1 source), edema in ventral trunk (1 source), increased pigmentation in the head (1 source), increased pigmentation in the optic stalk (1 source), increased size of the barbel (1 source), increased size of the eye (1 source), increased size of the head (1 source), wholly anterioralized embryo (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: nog manipulated (12 sources)
Computed annotations: nog manipulated (4 sources), nog assayed (32 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + nog (5 sources), Xla Wt + nog4 (5 sources), Xla Wt + nog4 MO (5 sources), Xla Wt + nog4 MO (4 sources), Xla Wt + Hsa.NOG (3 sources), Xla Wt + nog4 (3 sources), Xtr Wt + nog CRISPR (2 sources), Xtr Wt + rspo2 CRISPR + nog CRISPR (2 sources), Xla Wt + chrd MO + nog MO (1 source), Xla Wt + chrd MO + nog MO (1 source), Xla Wt + nog (1 source), Xla Wt + nog (1 source), Xla Wt + nog (1 source), Xla Wt + nog + epha4 MO + animal cap explant (1 source), Xla Wt + nog + sipa1l3 MO + animal cap explant (1 source), Xla Wt + nog + vegt + cyp26a1 + Retinoic acid + animal cap explant (1 source), Xla Wt + nog + vegt + cyp26a1 + Retinoic acid + CHX + animal cap explant (1 source), Xla Wt + nog - animal cap explant (1 source), Xla Wt + nog4 + dnbmpr1a (1 source), Xla Wt + nog4 MO (1 source), Xla Wt + nog4-EGFP + dnbmpr1a (1 source), Xla Wt + vegt + nog + cyp26a1 + CHX + animal cap explant (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (88 sources): 2-3 toe syndactyly, Abnormal vertebral morphology, Abnormality of the ankles, Abnormality of the metacarpal bones, Abnormality of the nail, Abnormality of the wrist, Absent distal interphalangeal creases, Absent distal phalanges, Absent fingernail, Absent phalangeal crease, [+]
Mouse (78 sources): abnormal Rathke's pouch apoptosis, abnormal Rathke's pouch development, abnormal apical ectodermal ridge morphology, abnormal basicranium morphology, abnormal bone mineralization, abnormal cartilage development, abnormal cochlea morphology, abnormal craniofacial morphology, abnormal diencephalon morphology, abnormal ear development, [+]

View all ortholog results at Monarch