Asthma, Bone pain, Budd-Chiari syndrome, Chronic diarrhea, Constitutional symptom, Decreased T cell activation, Defective B cell activation, Diarrhea, Dyspnea, Eczematoid dermatitis, Elevated circulating hepatic transaminase concentration, Epigastric pain, Esophageal varix, Failure to thrive, Fatigue, Fever, Hemobilia, Hepatic encephalopathy, Hepatic necrosis, Hepatocellular carcinoma, Hepatomegaly, Hyperbilirubinemia, Hypercalcemia, Hypoalbuminemia, Hypoglycemia, Hypokalemia, Hyponatremia, Hypotension, Internal hemorrhage, Jaundice, Liver abscess, Lymphadenopathy, Metabolic alkalosis, Micronodular cirrhosis, Neoplasm, obsolete Mood changes, Pedal edema, Pneumonia, Polycythemia, Poor appetite, Portal hypertension, Recurrent sinopulmonary infections, Short stature, Splenomegaly, Subacute progressive viral hepatitis, Thrombocytopenia, Thrombocytosis, Type II diabetes mellitus, Venous insufficiency, Weight loss

abnormal myeloblast morphology/development, abnormal myocardium layer morphology, abnormal response/metabolism to endogenous compounds, abnormal T cell activation, abnormal T cell proliferation, abnormal T cell subpopulation ratio, abnormal visceral yolk sac morphology, abnormal vitelline vascular remodeling, abnormal vitelline vasculature morphology, acanthosis, decreased B-1 B cell number, decreased B cell proliferation, decreased body size, decreased CD4-positive, alpha beta T cell number, decreased CD8-positive, naive alpha-beta T cell number, decreased embryo size, decreased marginal zone B cell number, decreased sensitivity to induced morbidity/mortality, decreased susceptibility to injury, decreased T cell apoptosis, decreased T cell proliferation, dermatitis, embryonic lethality, complete penetrance, embryonic lethality during organogenesis, complete penetrance, embryonic lethality during organogenesis, incomplete penetrance, enlarged lymph nodes, epidermal hyperplasia, epidermal spongiosis, hematopoietic system phenotype, impaired hematopoiesis, impaired skin barrier function, increased apoptosis, increased cardiomyocyte apoptosis, increased CD8-positive, alpha-beta T cell number, increased effector memory CD4-positive, alpha-beta T cell number, increased effector memory CD8-positive, alpha-beta T cell number, increased erythrocyte cell number, increased IgG1 level, increased susceptibility to injury, kinked neural tube, lymphoid hyperplasia, pale yolk sac, pericardial edema, postnatal lethality, incomplete penetrance, premature death, prenatal lethality, complete penetrance, skin edema, small liver, thin myocardium, thin ventricular wall, visceral vascular congestion, wavy neural tube