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Summary Expression Phenotypes Gene Literature (55) GO Terms (20) Nucleotides (216) Proteins (54) Interactants (667) Wiki

hes1     hes family bHLH transcription factor 1

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal cell migration in neural crest (2 sources), abnormally decreased number of apoptotic cell (1 source), abnormally increased number of apoptotic cell (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: hes1 manipulated (12 sources), hes1 assayed (2 sources)
Computed annotations: hes1 assayed (16 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + hes1-GR + DEX (3 sources), Xla Wt + dnhes1-GR + DEX (3 sources), Xla Wt + hes1-GR + DEX (2 sources), Xla Wt + hes1-GR + DEX + aphidicolin + hydroxyurea (2 sources), Xla Wt + dnhes1-GR + DEX (2 sources), Xla Wt + dnhes1-GR + DEX + aphidicolin + hydroxyurea (2 sources)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (47 sources): abnormal T cell differentiation, abnormal bile duct development, abnormal bile duct morphology, abnormal brain development, abnormal cell differentiation, abnormal cochlear hair cell morphology, abnormal cystic duct morphology, abnormal exocrine pancreas morphology, abnormal extrahepatic bile duct morphology, abnormal nasal placode morphology, [+]