abnormal circulating interferon level, abnormal circulating total protein level, abnormal cytokine level, abnormal cytotoxic T cell physiology, abnormal dendritic cell antigen presentation, abnormal dendritic cell chemotaxis, abnormal dendritic cell physiology, abnormal diapedesis, abnormal erythropoiesis, abnormal heart echocardiography feature, abnormal hematopoietic stem cell morphology, abnormal humoral immune response, abnormal immune tolerance, abnormal interferon-gamma secretion, abnormal lung volume, abnormal lymph node cell ratio, abnormal macrophage chemotaxis, abnormal macrophage physiology, abnormal maternal decidual layer morphology, abnormal myocardial fiber morphology, abnormal nitric oxide homeostasis, abnormal pancreatic beta cell physiology, abnormal proerythroblast morphology, abnormal redox activity, abnormal response to infection, abnormal response to injury, abnormal response to new environment, abnormal response to transplant, abnormal seminal vesicle morphology, abnormal spleen red pulp morphology, abnormal spleen white pulp morphology, abnormal susceptibility to infection, abnormal thoracic cavity morphology, abnormal tumor pathology, abnormal type IV hypersensitivity reaction, abnormal uterine NK cell morphology, abnormal uterine NK cell physiology, cardiac interstitial fibrosis, cardiac muscle atrophy, cardiac muscle degeneration, decreased IgG2a level, decreased IgG2b level, decreased IgG3 level, decreased airway responsiveness, decreased anti-double stranded DNA antibody level, decreased anti-nuclear antigen antibody level, decreased apoptosis, decreased autoantibody level, decreased body size, decreased bone marrow cell number, decreased cardiac muscle contractility, decreased common myeloid progenitor cell number, decreased erythrocyte cell number, decreased granulocyte monocyte progenitor cell number, decreased interferon-gamma secretion, decreased interleukin-10 secretion, decreased length of allograft survival, decreased litter size, decreased mature B cell number, decreased megakaryocyte-erythroid progenitor cell number, decreased myeloid cell number in bone marrow, decreased physiological sensitivity to xenobiotic, decreased pre-B cell number, decreased susceptibility to autoimmune diabetes, decreased susceptibility to autoimmune disorder, decreased susceptibility to injury, decreased susceptibility to parasitic infection, decreased susceptibility to parasitic infection induced morbidity/mortality, decreased susceptibility to type IV hypersensitivity reaction, decreased tumor incidence, decreased tumor latency, decreased vertical activity, diffuse hepatic necrosis, dilated heart left ventricle, embryonic lethality prior to organogenesis, embryonic lethality prior to tooth bud stage, enlarged mesenteric lymph nodes, focal hepatic necrosis, immune system phenotype, impaired hematopoiesis, impaired natural killer cell mediated cytotoxicity, impaired skeletal muscle regeneration, increased CD8-positive, alpha-beta T cell number, increased IgG1 level, increased NK T cell number, increased T cell derived lymphoma incidence, increased airway responsiveness, increased apoptosis, increased circulating alanine transaminase level, increased circulating interleukin-12 level, increased circulating interleukin-6 level, increased erythroblast number, increased erythrocyte cell number, increased fear-related response, increased granulocyte number, increased hematopoietic stem cell number, increased interleukin-10 secretion, increased interleukin-12 secretion, increased interleukin-17 secretion, increased interleukin-2 secretion, increased interleukin-4 secretion, increased interleukin-5 secretion, increased lung compliance, increased lymphoma incidence, increased macrophage cell number, increased metastatic potential, increased neutrophil cell number, increased nucleated erythrocyte cell number, increased sensitivity to xenobiotic induced morbidity/mortality, increased splenocyte proliferation, increased susceptibility to Coronaviridae infection, increased susceptibility to Coronaviridae infection induced morbidity/mortality, increased susceptibility to Herpesvirales infection, increased susceptibility to Herpesvirales infection induced morbidity/mortality, increased susceptibility to bacterial infection induced morbidity/mortality, increased susceptibility to experimental autoimmune encephalomyelitis, increased susceptibility to parasitic infection, increased susceptibility to parasitic infection induced morbidity/mortality, increased susceptibility to type IV hypersensitivity reaction, increased tumor latency, increased uterine NK cell number, liver vascular congestion, neonatal lethality, incomplete penetrance, no abnormal phenotype detected, pale spleen, postnatal lethality, complete penetrance, premature death, preweaning lethality, complete penetrance, skeletal muscle fibrosis, spleen atrophy, thymus atrophy