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Summary Expression Phenotypes Gene Literature (31) GO Terms (12) Nucleotides (276) Proteins (34) Interactants (774) Wiki
XB-GENEPAGE-489345

rab11a     RAB11A, member RAS oncogene family

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased size of the trachea (3 sources), abnormal development of transient tracheoesophageal septum (2 sources), abnormal tracheoesophageal fold morphology (2 sources), abnormal development of blastopore (1 source), abnormal development of upper blastopore lip (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: rab11a manipulated (3 sources), rab11a assayed (6 sources)
Computed annotations: rab11a assayed (2 sources)
Diseases
Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
esophageal atresia/tracheoesophageal fistula (3AP sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + rab11a MO (3 sources), Xla Wt + dnrab11 (2 sources), Xla Wt + Doxycycline hyclate + Tg(hhex:rtTA;TRE:dnRab11a-GFP) (1 source), Xla Wt + rab11a CRISPR (1 source), Xla Wt + rab11a MO (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (29 sources): abnormal crypts of Lieberkuhn morphology, abnormal egg cylinder morphology, abnormal embryo size, abnormal embryo turning, abnormal intestinal epithelium morphology, abnormal intestinal goblet cell morphology, abnormal intestine physiology, abnormal mean corpuscular hemoglobin, abnormal small intestinal crypt cell proliferation, absent head fold, [+]