rab11a Phenotypes

Phenotypes

XB-GENEPAGE-489345

Gene Symbol: rab11a Gene Name: RAB11A, member RAS oncogene family

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
decreased size of the trachea (3 sources), abnormal development of transient tracheoesophageal septum (2 sources), abnormal tracheoesophageal fold morphology (2 sources), abnormal development of blastopore (1 source), abnormal development of upper blastopore lip (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: rab11a manipulated (3 sources), rab11a assayed (6 sources)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
esophageal atresia/tracheoesophageal fistula (3AP sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + rab11a MO (3 sources), Xla Wt + dnrab11 (2 sources), Xla Wt + Doxycycline hyclate + Tg(hhex:rtTA;TRE:dnRab11a-GFP) (1 source), Xla Wt + rab11a CRISPR (1 source), Xla Wt + rab11a MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (29 sources): abnormal crypts of Lieberkuhn morphology, abnormal egg cylinder morphology, abnormal embryo size, abnormal embryo turning, abnormal intestinal epithelium morphology, abnormal intestinal goblet cell morphology, abnormal intestine physiology, abnormal mean corpuscular hemoglobin, abnormal small intestinal crypt cell proliferation, absent head fold, absent primitive node, decreased body size, decreased colon length, decreased embryo size, decreased mean corpuscular hemoglobin, decreased mean corpuscular volume, decreased small intestinal villus size, embryonic growth arrest, embryonic lethality prior to organogenesis, embryonic lethality, complete penetrance, failure of primitive streak formation, failure to gastrulate, improved glucose tolerance, increased interleukin-1 beta secretion, increased interleukin-6 secretion, persistence of hyaloid vascular system, postnatal lethality, incomplete penetrance, premature death, preweaning lethality, complete penetrance [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (29 sources): abnormal crypts of Lieberkuhn morphology, abnormal egg cylinder morphology, abnormal embryo size, abnormal embryo turning, abnormal intestinal epithelium morphology, abnormal intestinal goblet cell morphology, abnormal intestine physiology, abnormal mean corpuscular hemoglobin, abnormal small intestinal crypt cell proliferation, absent head fold, [+]