| Monarch Ortholog Phenotypes
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Human (9 sources):
Decreased mean platelet volume,
Elevated erythrocyte sedimentation rate,
Failure to thrive,
Inflammation of the large intestine,
Lymphadenopathy,
Lymphocytosis,
Recurrent infections,
Thrombocytopenia,
Vasculitis
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Mouse (26 sources):
abnormal bone mineralization,
abnormal circulating fructosamine level,
decreased CD4-positive, alpha beta T cell number,
decreased KLRG1-positive NK cell number,
decreased Ly6C-positive mature NK cell number,
decreased bone mineral content,
decreased circulating fructosamine level,
decreased macrophage cell number,
decreased marginal zone precursor B cell number,
decreased mature NK cell number,
decreased transitional stage T2 B cell number,
fusion of vertebral arches,
increased CD103-positive CD11b-low dendritic cell number,
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number,
increased CD4-positive, alpha-beta memory T cell number,
increased KLRG1+ CD4 alpha beta T cell number,
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number,
increased KLRG1-positive T-helper cell number,
increased effector memory T-helper cell number,
increased immature NK cell number,
increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number,
increased memory-marker CD4-negative NK T cell number,
increased memory-marker NK cell number,
increased plasma cell number,
pigment incontinence,
skin fibrosis
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.