edn1 Phenotypes

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Phenotypes

Gene Literature (15)

Nucleotides (89)

Interactants (76)

XB-GENEPAGE-491327

Gene Symbol: edn1 Gene Name: endothelin 1

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: edn1 assayed (4 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (38 sources): Abnormal pinna morphology, Abnormality of the crus of the helix, Abnormality of the temporomandibular joint, Aplasia/Hypoplasia of the external ear, Bifid uvula, Bilateral conductive hearing impairment, Cleft helix, Cleft palate, Dental crowding, Dental malocclusion, Difficulty in tongue movements, Facial asymmetry, Feeding difficulties, Full cheeks, Generalized hypotonia, Global developmental delay, Glossoptosis, Hamartoma of tongue, Hearing impairment, Laryngeal cleft, Low-set, posteriorly rotated ears, Macrocephaly, Mandibular condyle aplasia, Mandibular condyle hypoplasia, Microglossia, Micrognathia, Narrow mouth, Obstructive sleep apnea, Periauricular skin pits, Preauricular skin tag, Ptosis, Question mark ear, Respiratory distress, Retrognathia, Snoring, Stenosis of the external auditory canal, Vein of Galen aneurysmal malformation, obsolete External ear malformation [+]
Mouse (32 sources): abnormal Meckel's cartilage morphology, abnormal carotid artery morphology, abnormal craniofacial morphology, abnormal first pharyngeal arch morphology, abnormal fourth pharyngeal arch artery morphology, abnormal pharyngeal arch artery morphology, abnormal sympathetic nervous system physiology, absent hyoid bone, absent right subclavian artery, absent submandibular gland, aorta tubular hypoplasia, cardiovascular system phenotype, decreased circulating antidiuretic hormone level, decreased mean systemic arterial blood pressure, decreased response of heart to induced stress, decreased systemic arterial diastolic blood pressure, decreased systemic arterial systolic blood pressure, decreased urine sodium level, embryo phenotype, hypoxia, increased mean systemic arterial blood pressure, increased systemic arterial blood pressure, increased systemic arterial systolic blood pressure, increased urine osmolality, interrupted aorta, mandible hypoplasia, neonatal lethality, complete penetrance, no abnormal phenotype detected, perinatal lethality, complete penetrance, renal/urinary system phenotype, salt-sensitive hypertension, small second pharyngeal arch [+]
View all ortholog results at Monarch