| Monarch Ortholog Phenotypes
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Human (10 sources):
Amblyopia,
Developmental cataract,
Diffuse nuclear cataract,
Microcornea,
Nuclear cataract,
Nystagmus,
Photophobia,
Posterior polar cataract,
Pulverulent cataract,
Visual impairment
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Mouse (34 sources):
Purkinje cell degeneration,
abnormal Purkinje cell dendrite morphology,
abnormal Purkinje cell morphology,
abnormal angiogenesis,
abnormal astrocyte morphology,
abnormal cell migration,
abnormal cell morphology,
abnormal cellular extravasation,
abnormal cerebellar Purkinje cell layer,
abnormal lens fiber morphology,
abnormal leukocyte adhesion,
abnormal leukocyte migration,
abnormal leukocyte tethering or rolling,
abnormal locomotor behavior,
abnormal motor learning,
abnormal vasoconstriction,
abnormal vasodilation,
cardiovascular system phenotype,
cellular phenotype,
decreased Purkinje cell number,
decreased mean systemic arterial blood pressure,
disorganized secondary lens fibers,
embryo phenotype,
homeostasis/metabolism phenotype,
immune system phenotype,
impaired balance,
increased anxiety-related response,
increased circulating creatinine level,
increased granulocyte number,
increased sensitivity to induced morbidity/mortality,
nervous system phenotype,
reproductive system phenotype,
respiratory system phenotype,
ruptured lens capsule
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.