traf2 Phenotypes

Phenotypes

XB-GENEPAGE-493459

Gene Symbol: traf2 Gene Name: TNF receptor associated factor 2

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: traf2 assayed (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (32 sources): abnormal placenta morphology, abnormal placental labyrinth vasculature morphology, abnormal spleen marginal zone morphology, absent follicular B cells, absent marginal zone B cells, absent spleen germinal center, decreased alpha-beta T cell number, decreased body fat mass, decreased body size, decreased double-positive T cell number, decreased immature B cell number, decreased mature B cell number, decreased skeletal muscle mass, decreased thymocyte number, enlarged lymph nodes, increased circulating tumor necrosis factor level, increased follicular B cell number, increased granulocyte number, increased marginal zone B cell number, increased sensitivity to induced cell death, increased thymocyte apoptosis, lethality throughout fetal growth and development, complete penetrance, lethality throughout fetal growth and development, incomplete penetrance, lymphoid hypoplasia, perinatal lethality, incomplete penetrance, placenta hemorrhage, placenta necrosis, postnatal lethality, incomplete penetrance, prenatal lethality, complete penetrance, preweaning lethality, complete penetrance, spleen atrophy, thymus atrophy [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (32 sources): abnormal placenta morphology, abnormal placental labyrinth vasculature morphology, abnormal spleen marginal zone morphology, absent follicular B cells, absent marginal zone B cells, absent spleen germinal center, decreased alpha-beta T cell number, decreased body fat mass, decreased body size, decreased double-positive T cell number, [+]