| Monarch Ortholog Phenotypes
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Human (5 sources):
Hypoalbuminemia,
Minimal change glomerulonephritis,
Nephrotic syndrome,
Proteinuria,
Stage 5 chronic kidney disease
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Mouse (32 sources):
abnormal brain interneuron morphology,
abnormal dendritic spine morphology,
abnormal endoplasmic reticulum morphology,
abnormal excitatory postsynaptic potential,
abnormal glomerular capsule parietal layer morphology,
abnormal glomerular filtration barrier function,
abnormal nest building behavior,
abnormal podocyte foot process morphology,
abnormal podocyte morphology,
abnormal podocyte slit diaphragm morphology,
abnormal social investigation,
abnormal spatial working memory,
abnormal sweet taste sensitivity,
absent glomerular endothelium fenestra,
absent podocytes,
cortical renal glomerulopathies,
decreased prepulse inhibition,
enlarged lateral ventricles,
fused podocyte foot processes,
glomerular crescent,
increased anxiety-related response,
increased circulating creatinine level,
neonatal lethality, complete penetrance,
nervous system phenotype,
no abnormal phenotype detected,
podocyte foot process effacement,
podocyte hypertrophy,
podocyte microvillus transformation,
postnatal lethality, complete penetrance,
premature death,
reduced long term potentiation,
renal cast
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.