| Monarch Ortholog Phenotypes
|
Human (31 sources):
Abnormal blistering of the skin,
Abnormal pulmonary interstitial morphology,
Decreased glomerular filtration rate,
Erythema,
Fine hair,
Focal segmental glomerulosclerosis,
Fragile skin,
Gynecomastia,
Hypertelorism,
Hypoalbuminemia,
Hypotonia,
Macrotia,
Microcephaly,
Nail dystrophy,
Narrow chest,
Narrow mouth,
Neonatal respiratory distress,
Nephrotic syndrome,
Onycholysis,
Prominent forehead,
Prominent nose,
Proteinuria,
Recurrent respiratory infections,
Renal insufficiency,
Renal tubular atrophy,
Respiratory acidosis,
Respiratory distress,
Round face,
Sparse eyelashes,
Sparse scalp hair,
obsolete Sparse and thin eyebrow
[+]
|
Mouse (27 sources):
abnormal bronchiole epithelium morphology,
abnormal distal convoluted tubule morphology,
abnormal kidney collecting duct morphology,
abnormal podocyte morphology,
abnormal proximal convoluted tubule morphology,
abnormal renal glomerulus basement membrane morphology,
abnormal spatial working memory,
absent podocyte foot process,
decreased glomerular capillary number,
decreased kidney collecting duct number,
decreased lung compliance,
dilated glomerular capillary,
dilated proximal convoluted tubule,
enhanced wound healing,
impaired branching involved in bronchus morphogenesis,
increased renal glomerulus basement membrane thickness,
increased type II pneumocyte number,
neonatal lethality, complete penetrance,
nervous system phenotype,
pale kidney,
podocyte foot process effacement,
pulmonary hyperplasia,
reduced long term potentiation,
renal cast,
small kidney,
thick pulmonary interalveolar septum,
thick skin
[+]
|
View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.