| Monarch Ortholog Phenotypes
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Human (24 sources):
Abnormal cardiovascular system morphology,
Abnormal heart morphology,
Abnormal nasopharynx morphology,
Agenesis of corpus callosum,
Anal atresia,
Anteverted nares,
Aspiration,
Cleft palate,
Cleft upper lip,
Cryptorchidism,
Dysphagia,
Frontal bossing,
Gastroesophageal reflux,
Global developmental delay,
High palate,
Hypertelorism,
Hypospadias,
Posterior pharyngeal cleft,
Prominent forehead,
Smooth philtrum,
Telecanthus,
Thin upper lip vermilion,
Wide nasal bridge,
Widow's peak
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Mouse (27 sources):
abnormal axon morphology,
abnormal brain development,
abnormal cerebellar cortex morphology,
abnormal cerebellar lobule formation,
abnormal cerebellum external granule cell layer morphology,
abnormal cerebellum fissure morphology,
abnormal cerebellum lobule morphology,
abnormal cerebellum vermis lobule I morphology,
abnormal cerebellum vermis lobule II morphology,
abnormal cerebellum vermis lobule III morphology,
abnormal embryo development,
abnormal gastrulation,
abnormal learning/memory/conditioning,
abnormal midbrain development,
abnormal midbrain-hindbrain boundary development,
abnormal midbrain-hindbrain boundary morphology,
abnormal motor learning,
abnormal tectum morphology,
decreased inferior colliculus size,
ectopic Purkinje cell,
embryo phenotype,
embryonic growth retardation,
impaired limb coordination,
increased startle reflex,
muscle phenotype,
no abnormal phenotype detected,
prenatal lethality, complete penetrance
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.