lhx8 LIM homeobox 8
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
|abnormal roof of mouth morphology (3 sources), decreased width of the craniofacial region (3 sources), absent planum trabeculare anticum (2 sources), abnormal Meckel's cartilage morphology (1 source), abnormal basihyal morphology (1 source), abnormal ceratohyal morphology (1 source), abnormal infrarostral morphology (1 source), abnormal mouth morphology (1 source), abnormal palatoquadrati morphology (1 source), abnormal trabecula cranii morphology (1 source), absent suprarostral plate (1 source), decreased size of the craniofacial region (1 source), decreased size of the head mesenchyme (1 source)|
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
|Manual annotations: lhx8 assayed (1 source)|
|Computed annotations: lhx8 assayed (4 sources)|
These are short form descriptions of experiments using reagents targeting the gene of interest.
|Xla Wt + lhx8 MO + msx2 MO (4 sources), Xla Wt + lhx8 MO (1 source), Xla Wt + lhx8 MO + msx2 MO (1 source), Xla Wt + lhx8 MO + msx2 MO + BMS453 (1 source), Xtr Wt + lhx8 + animal cap explant (0 sources)|
|Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (13 sources):
abnormal GABAergic neuron morphology,
abnormal brain interneuron morphology,
abnormal cholinergic neuron morphology,
abnormal contextual conditioning behavior,
abnormal dorsal striatum morphology,
abnormal neuron differentiation,
abnormal spatial learning,
abnormal telencephalon development,
neonatal lethality, incomplete penetrance,
palatal shelves fail to meet at midline, premature death, preweaning lethality, incomplete penetrance[+]