| Monarch Ortholog Phenotypes
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Human (1 source):
Increased circulating ferritin concentration
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Mouse (20 sources):
abnormal embryo size,
abnormal mitochondrial physiology,
abnormal neuron physiology,
decreased spleen iron level,
embryonic lethality prior to organogenesis,
embryonic lethality prior to tooth bud stage,
embryonic lethality, complete penetrance,
increased circulating alanine transaminase level,
increased circulating aspartate transaminase level,
increased circulating ferritin level,
increased circulating iron level,
increased liver weight,
increased sensitivity to induced cell death,
increased sensitivity to induced morbidity/mortality,
liver hemorrhage,
liver/biliary system phenotype,
macrovesicular hepatic steatosis,
oxidative stress,
prenatal lethality, complete penetrance,
preweaning lethality, complete penetrance
[+]
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.