hmgn1 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-5782072

Gene Symbol: hmgn1 Gene Name: high mobility group nucleosome binding domain 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal Meckel's cartilage morphology (1 source), abnormal ceratohyal morphology (1 source), abnormal chondrocranium morphology (1 source), abnormal cranial neural crest (1 source), abnormal gill primordium morphology (1 source), decreased cell migration in branchial crest (1 source), decreased cell migration in hyoid crest (1 source), decreased cell migration in mandibular crest (1 source), decreased size of the chondrocranium (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormal Meckel's cartilage morphology (1 source), abnormal ceratohyal morphology (1 source), abnormal chondrocranium morphology (1 source), abnormal cranial neural crest (1 source), abnormal gill primordium morphology (1 source), decreased cell migration in branchial crest (1 source), decreased cell migration in hyoid crest (1 source), decreased cell migration in mandibular crest (1 source), decreased size of the chondrocranium (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: hmgn1 manipulated (3 sources)
Computed annotations: hmgn1 assayed (1 source)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
microcephaly (1AP source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + hmgn1 MO (5 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (15 sources): abnormal cell cycle checkpoint function, decreased prepulse inhibition, decreased startle reflex, decreased vertical activity, embryonic lethality during organogenesis, incomplete penetrance, increased cellular sensitivity to gamma-irradiation, increased cellular sensitivity to ultraviolet irradiation, increased fibroblast proliferation, increased hemangioma incidence, increased incidence of tumors by ionizing radiation induction, increased malignant tumor incidence, increased metastatic potential, increased mortality induced by gamma-irradiation, increased sensitivity to skin irradiation, increased tumor incidence [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (15 sources): abnormal cell cycle checkpoint function, decreased prepulse inhibition, decreased startle reflex, decreased vertical activity, embryonic lethality during organogenesis, incomplete penetrance, increased cellular sensitivity to gamma-irradiation, increased cellular sensitivity to ultraviolet irradiation, increased fibroblast proliferation, increased hemangioma incidence, increased incidence of tumors by ionizing radiation induction, [+]