| Monarch Ortholog Phenotypes
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Human (7 sources):
Eczematoid dermatitis,
Impaired platelet aggregation,
Menorrhagia,
Psoriasiform dermatitis,
Recurrent viral infections,
Thrombocytopenia,
obsolete Hypotrichosis
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Mouse (42 sources):
abnormal arteriole morphology,
abnormal brain meninges morphology,
abnormal class switch recombination,
abnormal erythropoiesis,
abnormal humoral immune response,
abnormal megakaryocyte differentiation,
abnormal megakaryocyte morphology,
abnormal megakaryocyte progenitor cell morphology,
abnormal pericyte morphology,
abnormal proerythroblast morphology,
abnormal splenic cell ratio,
abnormal thrombopoiesis,
abnormal vascular development,
abnormal vascular smooth muscle morphology,
abnormal venule morphology,
decreased B cell proliferation,
decreased IgG1 level,
decreased IgG3 level,
decreased embryo size,
decreased follicular B cell number,
decreased granulocyte number,
decreased hematocrit,
decreased thymocyte number,
dilated capillary,
embryonic lethality during organogenesis, complete penetrance,
hematopoietic system phenotype,
impaired hematopoiesis,
increased NK cell number,
increased erythrocyte cell number,
increased marginal zone B cell number,
increased thymocyte number,
increased transitional stage B cell number,
increased vascular endothelial cell number,
increased vascular permeability,
pale liver,
pale yolk sac,
perinatal lethality, incomplete penetrance,
prenatal lethality, complete penetrance,
small liver,
spinal hemorrhage,
spleen hyperplasia,
vascular stenosis
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.