ptbp1 Phenotypes

Phenotypes

XB-GENEPAGE-5818205

Gene Symbol: ptbp1 Gene Name: polypyrimidine tract binding protein 1

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
obsolete abnormally edematous dorsal fin (4 sources), abnormal goblet cell morphology (1 source), abnormally increased number of goblet cell (1 source), absent epidermis inner layer (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: ptbp1 manipulated (1 source)
Computed annotations: ptbp1 assayed (2 sources)

Diseases Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
squamous cell carcinoma (1 EP source)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + ptbp1 MO (6 sources), Xla Wt + ptbp1 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (23 sources): abnormal Reichert's membrane morphology, abnormal brain ependyma morphology, abnormal brain ependyma motile cilium morphology, abnormal ectoplacental cone morphology, abnormal endoderm development, abnormal gastrulation, abnormal nervous system development, abnormal neuronal stem cell morphology, abnormal telencephalon morphology, abnormal visceral yolk sac morphology, absent blastocoele, decreased cell proliferation, decreased embryo size, domed cranium, ectopic neuron, embryonic growth retardation, embryonic lethality between implantation and somite formation, complete penetrance, embryonic lethality during organogenesis, complete penetrance, increased apoptosis, increased astrocyte number, nervous system phenotype, premature death, premature neuronal precursor differentiation [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (23 sources): abnormal Reichert's membrane morphology, abnormal brain ependyma morphology, abnormal brain ependyma motile cilium morphology, abnormal ectoplacental cone morphology, abnormal endoderm development, abnormal gastrulation, abnormal nervous system development, abnormal neuronal stem cell morphology, abnormal telencephalon morphology, abnormal visceral yolk sac morphology, [+]