asxl3 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-5858667

Gene Symbol: asxl3 Gene Name: ASXL transcriptional regulator 3

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal anterior neural tube morphology (2 sources), abnormal head morphology (2 sources), abnormal neural tube closure (2 sources), abnormal anatomical axis (1 source), abnormal anterior-posterior axis, curved lateral (1 source), abnormal cartilage tissue (1 source), abnormal cell migration in neural crest (1 source), abnormal chondrocranium (1 source), abnormal neural crest morphology (1 source), abnormal neural plate morphology (1 source), abnormal trunk region (1 source), arrested axis elongation (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormal anterior neural tube morphology (2 sources), abnormal head morphology (2 sources), abnormal neural tube closure (2 sources), abnormal anatomical axis (1 source), abnormal anterior-posterior axis, curved lateral (1 source), abnormal cartilage tissue (1 source), abnormal cell migration in neural crest (1 source), abnormal chondrocranium (1 source), abnormal neural crest morphology (1 source), abnormal neural plate morphology (1 source), abnormal trunk region (1 source), arrested axis elongation (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: asxl3 manipulated (9 sources)
Computed annotations: asxl3 assayed (2 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla + asxl3 MO (8 sources), Xla Wt + asxl3 MO (2 sources), Xla Wt + asxl3 MO + animal cap amputation (2 sources), Xla Wt + meis3 + asxl3 MO (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (53 sources): Abnormal cerebral white matter morphology, Abnormality of the skeletal system, Absent speech, Anteverted nares, Arachnodactyly, Autistic behavior, Broad nasal tip, Bulbous nose, Cerebellar vermis hypoplasia, Decreased facial expression, Delayed ability to walk, Dental crowding, Disproportionate tall stature, Dolichocephaly, Downslanted palpebral fissures, Everted lower lip vermilion, Failure to thrive, Feeding difficulties, Feeding difficulties in infancy, Generalized hypotonia, Global developmental delay, High palate, High, narrow palate, Highly arched eyebrow, Hypertelorism, Hypoplasia of the corpus callosum, Inability to walk, Infantile muscular hypotonia, Intellectual disability, Intellectual disability, moderate, Intellectual disability, profound, Intellectual disability, severe, Long nose, Low hanging columella, Microcephaly, Neurological speech impairment, Open mouth, Pes planus, Prominent forehead, Prominent nasal bridge, Recurrent hand flapping, Scoliosis, Seizure, Severe global developmental delay, Severe postnatal growth retardation, Short nose, Sleep disturbance, Spasticity, Strabismus, Synophrys, Underdeveloped nasal alae, Upslanted palpebral fissure, Wide mouth [+]
Mouse (4 sources): abnormal circulating amylase level, abnormal circulating fructosamine level, decreased circulating amylase level, decreased circulating fructosamine level
View all ortholog results at Monarch