| Monarch Ortholog Phenotypes
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Human (41 sources):
Abnormal eye physiology,
Abnormal internal carotid artery morphology,
Abnormal left ventricular function,
Abnormal nervous system physiology,
Abnormal tendon morphology,
Acanthocytosis,
Angina pectoris,
Aortic atherosclerotic lesion,
Arthralgia,
Ataxia,
Calcification of the aorta,
Cerebral artery atherosclerosis,
Corneal arcus,
Coronary artery aneurysm,
Coronary artery atherosclerosis,
Decreased LDL cholesterol concentration,
Dyspnea,
Heart murmur,
Hepatic steatosis,
Hypercholesterolemia,
Hyperlipidemia,
Hypertension,
Increased LDL cholesterol concentration,
Mitral regurgitation,
Myocardial infarction,
Myocardial steatosis,
Optic neuropathy,
Peripheral arterial stenosis,
Precocious atherosclerosis,
Premature arteriosclerosis,
Premature coronary artery atherosclerosis,
Reduced tendon reflexes,
Renal artery stenosis,
Renal steatosis,
Retinal degeneration,
Rod-cone dystrophy,
Sudden cardiac death,
Supravalvular aortic stenosis,
Tendon xanthomatosis,
Xanthelasma,
Xanthomatosis
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Mouse (15 sources):
abnormal blood homeostasis,
abnormal circulating cholesterol level,
abnormal embryo development,
abnormal triglyceride level,
abnormal visceral yolk sac endoderm morphology,
asthenozoospermia,
decreased embryo size,
embryonic lethality during organogenesis, incomplete penetrance,
herniated liver,
homeostasis/metabolism phenotype,
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.