| Monarch Ortholog Phenotypes
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Human (32 sources):
Abnormal lower motor neuron morphology,
Abnormality of extrapyramidal motor function,
Abnormality of metabolism/homeostasis,
Apathy,
Bradykinesia,
Central hypoventilation,
Dementia,
Depression,
Distal amyotrophy,
Distal muscle weakness,
Dysarthria,
Facial palsy,
Frontotemporal dementia,
Hand muscle atrophy,
Hand muscle weakness,
Hypotension,
Hypoventilation,
Inappropriate behavior,
Insomnia,
Lower limb muscle weakness,
Mask-like facies,
Parkinsonism,
Personality changes,
Respiratory insufficiency,
Rigidity,
Short stepped shuffling gait,
Sleep disturbance,
Tremor,
Vertical supranuclear gaze palsy,
Vocal cord paralysis,
Weak voice,
Weight loss
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Mouse (16 sources):
abnormal gastrulation,
abnormal neuromuscular synapse morphology,
absent somites,
decreased gastrocnemius weight,
decreased motor neuron number,
decreased vertical activity,
embryonic growth arrest,
embryonic lethality, complete penetrance,
increased apoptosis,
increased circulating creatinine level,
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.