| Monarch Ortholog Phenotypes
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Human (10 sources):
Absence of lymph node germinal center,
Decreased circulating IgA level,
Decreased circulating IgE,
Decreased circulating IgG level,
Immunodeficiency,
Impaired Ig class switch recombination,
Impaired memory B cell generation,
Increased circulating IgM level,
Neutropenia,
Recurrent bacterial infections
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Mouse (21 sources):
abnormal dendritic cell physiology,
abnormal humoral immune response,
abnormal lymph node germinal center morphology,
abnormal response to transplant,
absent germinal center B cells,
absent spleen germinal center,
decreased IgG1 level,
decreased IgG2a level,
decreased IgG2b level,
decreased IgG3 level,
decreased cerebral infarct size,
decreased circulating glucose level,
decreased compact bone mass,
decreased spleen germinal center number,
decreased spleen germinal center size,
decreased susceptibility to type II hypersensitivity reaction,
decreased trabecular bone mass,
hematopoietic system phenotype,
immune system phenotype,
impaired humoral immune response,
increased IgG3 level
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.