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XB-GENEPAGE-5966550
thra thyroid hormone receptor alpha
Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology
covering anatomical, gene ontology, and neurobehavioral phenotypes.
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abnormally peramorphic growth of hindlimb bud (4 sources), increased size of the hindlimb bud (4 sources), abnormal hindlimb bud (2 sources), delayed metamorphosis (2 sources), increased thickness of the epidermis (2 sources), increased width of hindlimb bud (2 sources), abnormal iridophore (1 source), abnormal regulation of growth rate (1 source), abnormal thyroid hormone metabolic process (1 source), decreased apoptosis in tail (1 source), decreased apoptosis in tail somite (1 source), decreased length of hindlimb (1 source), decreased width of the head (1 source), increased apoptosis in tail somite (1 source) |
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.
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Manual annotations: thra manipulated (1 source), thra assayed (2 sources) |
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting
the gene of interest.
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Xla Wt + thra TALEN (5 sources), Xtr wt + thra TALEN + mCherry (3 sources), Xla wt + Tg(thradn) + GFP (2 sources), Xla Wt + Tg(thradn) (1 source), Xtr Wt + TALEN thra (1 source) |
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
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Human (19 sources): Anemia, Broad-based gait, Congenital hip dislocation, Congenital hypothyroidism, Constipation, Delayed eruption of teeth, Delayed skeletal maturation, Drowsiness, Dry skin, Growth delay, [+] |
Mouse (118 sources): abnormal Purkinje cell dendrite morphology, abnormal adipose tissue amount, abnormal bone mineral content, abnormal bone mineralization, abnormal bone remodeling, abnormal bone strength, abnormal cerebellum external granule cell layer morphology, abnormal chondrocyte physiology, abnormal cochlear outer hair cell morphology, abnormal contextual conditioning behavior, [+] |
View all ortholog results at Monarch |