| Monarch Ortholog Phenotypes
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Human (34 sources):
Abnormality of movement,
Abnormality of retinal pigmentation,
Abnormal speech pattern,
Aphasia,
Apraxia,
Ataxia,
Bilateral tonic-clonic seizure,
Blurred vision,
Choreoathetosis,
Coma,
Confusion,
Diplopia,
Drowsiness,
Dysarthria,
Dystonia,
EEG abnormality,
Episodic ataxia,
Episodic hemiplegia,
Episodic quadriplegia,
Fever,
Hemiparesis,
Hemiplegia,
Hemiplegia/hemiparesis,
Intellectual disability,
Mental deterioration,
Migraine with aura,
Nystagmus,
obsolete Dysphasia,
Pigmentary retinopathy,
Seizure,
Sensorineural hearing impairment,
Tetraplegia,
Transient unilateral blurring of vision,
Vertigo
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Mouse (30 sources):
abnormal action potential,
abnormal amygdala morphology,
abnormal cardiac muscle contractility,
abnormal hippocampus physiology,
abnormal impulsive behavior control,
abnormal muscle contractility,
abnormal olfactory cortex morphology,
abnormal social investigation,
abnormal somatic nervous system physiology,
abnormal spatial learning,
abnormal synaptic neurotransmitter level,
abnormal systemic arterial blood pressure,
behavioral despair,
cardiac hypertrophy,
cardiovascular system phenotype,
decreased cardiac muscle contractility,
decreased locomotor activity,
embryo phenotype,
excessive vocalization,
homeostasis/metabolism phenotype,
increased anxiety-related response,
increased gamma-aminobutyric acid level,
increased glutamic acid level,
increased grooming behavior,
increased heart weight,
increased startle reflex,
neonatal lethality, complete penetrance,
no abnormal phenotype detected,
no spontaneous movement,
unresponsive to tactile stimuli
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.