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XB-GENEPAGE-6042438
h3-3a H3.3 histone A
Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology
covering anatomical, gene ontology, and neurobehavioral phenotypes.
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| decreased length of anterior-posterior axis (6 sources), abnormally delayed closure of blastopore (5 sources), abnormal gastrulation (4 sources), increased apoptosis in embryo (4 sources), decreased size of the head (3 sources), abnormal anterior-posterior axis morphology (2 sources), abnormal bending of anterior-posterior axis (1 source), abnormal incomplete closing of the neural tube (1 source) |
| Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.
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| Manual annotations: h3-3a manipulated (6 sources) |
| Computed annotations: h3-3a manipulated (3 sources) |
| Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting
the gene of interest.
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| Xla Wt + h3f3a MO (15 sources), Xla Wt + h3f3a MO (3 sources), WT + h3-3a.LK4M (1 source), WT + SCNT endoderm cell + h3-3a.L (1 source), WT + SCNT endoderm cell + h3-3a.LK4M (1 source), Xla Wt + h3f3a MO (1 source), Xla Wt + h3f3a MO (1 source), Xla Wt + h3f3a MO (1 source), Xla Wt + h3f3a MO (1 source) |
| Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
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| Mouse (6 sources): abnormal grip strength, decreased body size, neonatal lethality, incomplete penetrance, no abnormal phenotype detected, reduced female fertility, reduced male fertility |