| Monarch Ortholog Phenotypes
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Human (46 sources):
Abnormal blistering of the skin,
Abnormal eyebrow morphology,
Abnormal eyelid morphology,
Abnormality of the nail,
Abnormality of the tongue,
Alopecia of scalp,
Anorexia,
Ataxia,
Blepharitis,
Cerebral cortical atrophy,
Cheilitis,
Chronic diarrhea,
Conjunctivitis,
Corneal erosion,
Decreased serum testosterone concentration,
Decreased testicular size,
Diarrhea,
Dry skin,
Emotional lability,
Erythema,
Failure to thrive,
Furrowed tongue,
Generalized abnormality of skin,
Glossitis,
Hepatomegaly,
Hypogeusia,
Hypogonadism,
Impaired T cell function,
Irritability,
Lethargy,
Low alkaline phosphatase,
Malabsorption,
Paronychia,
Photophobia,
Poor appetite,
Pustule,
Recurrent candida infections,
Ridged fingernail,
Ridged nail,
Short stature,
Skin ulcer,
Splenomegaly,
Tremor,
Visual impairment,
Weight loss,
obsolete Hypotrichosis
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Mouse (29 sources):
abnormal Paneth cell morphology,
abnormal craniofacial development,
abnormal embryo development,
abnormal embryo size,
abnormal forebrain development,
abnormal hindbrain development,
abnormal midbrain development,
abnormal mineral homeostasis,
abnormal seminal vesicle morphology,
abnormal small intestinal crypt cell proliferation,
abnormal small intestine crypts of Lieberkuhn morphology,
decreased body size,
decreased bone mass,
decreased embryo size,
decreased intestinal iron level,
decreased intestine copper level,
decreased liver copper level,
decreased muscle weight,
embryonic growth retardation,
embryonic lethality during organogenesis, complete penetrance,
embryonic lethality during organogenesis, incomplete penetrance,
embryonic lethality prior to organogenesis,
embryonic lethality prior to tooth bud stage,
lethality at weaning, complete penetrance,
maternal effect,
postnatal lethality, incomplete penetrance,
premature death,
preweaning lethality, complete penetrance,
thick interventricular septum
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.