fyn Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-6053488

Gene Symbol: fyn Gene Name: FYN proto-oncogene, Src family tyrosine kinase

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Computed annotations: fyn assayed (2 sources)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Mouse (56 sources): abnormal CD4-positive, alpha-beta T cell physiology, abnormal Sertoli cell barrier morphology, abnormal T cell activation, abnormal T cell clonal deletion, abnormal T cell proliferation, abnormal chemokine level, abnormal dentate gyrus morphology, abnormal eosinophil physiology, abnormal excitatory postsynaptic potential, abnormal filiform papillae morphology, abnormal hippocampus layer morphology, abnormal hippocampus pyramidal cell layer, abnormal hippocampus pyramidal cell morphology, abnormal immune cell physiology, abnormal interleukin-4 secretion, abnormal keratinocyte differentiation, abnormal keratinocyte morphology, abnormal locomotor circadian rhythm, abnormal macrophage physiology, abnormal maternal nurturing, abnormal pup retrieval, abnormal seminiferous tubule morphology, abnormal somatosensory cortex morphology, abnormal spatial learning, abnormal startle reflex, abnormal stratification in cerebral cortex, abnormal suckling behavior, abnormal thymocyte activation, audiogenic seizures, decreased T cell proliferation, decreased body size, decreased corpus callosum size, decreased eating frequency, decreased gamma-delta T cell number, decreased interferon-gamma secretion, decreased interleukin-2 secretion, decreased testis weight, ectopic hippocampus pyramidal cells, enhanced behavioral response to alcohol, enhanced passive avoidance behavior, epidermal hyperplasia, increased IgG2a level, increased dopamine level, increased fear-related response, increased hippocampus pyramidal cell number, increased interleukin-5 secretion, increased sensitivity to xenobiotic induced morbidity/mortality, increased serotonin level, increased susceptibility to experimental autoimmune uveoretinitis, increased susceptibility to type I hypersensitivity reaction, increased tumor necrosis factor secretion, postnatal lethality, preweaning lethality, complete penetrance, prolonged circadian behavior period, reduced long term potentiation, small seminiferous tubules [+]

Monarch Ortholog Phenotypes

These phenotypes are associated with this gene with a has phenotype relation via Monarch.

Mouse (56 sources): abnormal CD4-positive, alpha-beta T cell physiology, abnormal Sertoli cell barrier morphology, abnormal T cell activation, abnormal T cell clonal deletion, abnormal T cell proliferation, abnormal chemokine level, abnormal dentate gyrus morphology, abnormal eosinophil physiology, abnormal excitatory postsynaptic potential, abnormal filiform papillae morphology, [+]