tbx6 Phenotypes

Summary

Expression

Phenotypes

XB-GENEPAGE-6257418

Gene Symbol: tbx6 Gene Name: T-box 6

Anatomical Phenotypes Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal anterior-posterior axis morphology (2 sources), decreased length of anterior-posterior axis (2 sources), wholly ventralized embryo (2 sources), abnormal development of tail (1 source), abnormally decreased number of somite (1 source), abnormally edematous pericardium (1 source), absent cement gland (1 source), absent eye (1 source), decreased length of tail (1 source), decreased size of the anterior neuroectoderm (1 source), decreased size of the head (1 source), decreased size of the tail bud (1 source), edema in ventral trunk (1 source), increased size of the anterior neuroectoderm (1 source), increased size of the head (1 source), increased size of the mesoderm in trunk (1 source), partially dorsalized embryo (1 source), tail abnormally curved dorsally (1 source)

Anatomical Phenotypes

Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.

abnormal anterior-posterior axis morphology (2 sources), decreased length of anterior-posterior axis (2 sources), wholly ventralized embryo (2 sources), abnormal development of tail (1 source), abnormally decreased number of somite (1 source), abnormally edematous pericardium (1 source), absent cement gland (1 source), absent eye (1 source), decreased length of tail (1 source), decreased size of the anterior neuroectoderm (1 source), decreased size of the head (1 source), decreased size of the tail bud (1 source), edema in ventral trunk (1 source), increased size of the anterior neuroectoderm (1 source), increased size of the head (1 source), increased size of the mesoderm in trunk (1 source), partially dorsalized embryo (1 source), tail abnormally curved dorsally (1 source)

Expression Phenotypes Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: tbx6 manipulated (3 sources), tbx6 assayed (3 sources)
Computed annotations: tbx6 assayed (14 sources)

Experiments (Reagents) These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + tbx6-VP16 (3 sources), Xla Wt + tbx6-VP16-GR + wnt8a MO (2 sources), Xtr Wt + tbx6 MO (2 sources), Xtr Wt + tbx6 MO (2 sources), Xla Wt + tbx6-EnR (1 source), Xla Wt + tbx6-VP16 (1 source), Xla Wt + tbx6-VP16-GR + DEX (1 source)

Monarch Ortholog Phenotypes These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (30 sources): Abnormal morphology of female internal genitalia, Abnormal sacrum morphology, Abnormality of cardiovascular system morphology, Abnormality of the ribs, Anteverted nares, Butterfly vertebrae, Cleft palate, Disproportionate short-trunk short stature, Hemivertebrae, Hyperlordosis, Intrauterine growth retardation, Low back pain, Macrocephaly, Microcephaly, Missing ribs, Pectus carinatum, Posterior rib fusion, Prominent occiput, Recurrent respiratory infections, Scoliosis, Severe short stature, Short neck, Short thorax, Spina bifida occulta, Supernumerary ribs, Syringomyelia, Upslanted palpebral fissure, Vertebral fusion, Vertebral segmentation defect, Wide nasal bridge [+]
Mouse (40 sources): abnormal cervical atlas morphology, abnormal cervical vertebrae morphology, abnormal digestive system development, abnormal direction of embryo turning, abnormal direction of heart looping, abnormal intersomitic artery morphology, abnormal intervertebral disk development, abnormal lumbar vertebrae morphology, abnormal mesoderm development, abnormal motile primary cilium morphology, abnormal notochord morphology, abnormal paraxial mesoderm morphology, abnormal somite development, abnormal tail development, abnormal thoracic vertebrae morphology, abnormal vascular development, abnormal vertebrae development, abnormal vertebral arch development, abnormal vertebral articular process morphology, abnormal vertebral body development, abnormal vertebral column morphology, abnormal vertebral transverse process morphology, cardiovascular system phenotype, decreased body length, embryo phenotype, embryonic lethality during organogenesis, complete penetrance, enlarged tail bud, enlarged vertebral body, fused somites, fusion of vertebral arches, fusion of vertebral bodies, hematoma, impaired somite development, kinked neural tube, kinked tail, prenatal lethality, complete penetrance, reduced female fertility, short tail, skeleton phenotype, small vertebral body [+]
View all ortholog results at Monarch