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Summary Expression Phenotypes Gene Literature (41) GO Terms (20) Nucleotides (219) Proteins (19) Interactants (958) Wiki

tbx6     T-box 6

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal anterior-posterior axis morphology (2 sources), decreased length of anterior-posterior axis (2 sources), wholly ventralized embryo (2 sources), abnormal development of tail (1 source), abnormally decreased number of somite (1 source), abnormally edematous pericardium (1 source), absent cement gland (1 source), absent eye (1 source), decreased length of tail (1 source), decreased size of the anterior neuroectoderm (1 source), decreased size of the head (1 source), decreased size of the tail bud (1 source), edema in ventral trunk (1 source), increased size of the anterior neuroectoderm (1 source), increased size of the head (1 source), increased size of the mesoderm in trunk (1 source), partially dorsalized embryo (1 source), tail abnormally curved dorsally (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: tbx6 manipulated (3 sources), tbx6 assayed (3 sources)
Computed annotations: tbx6 assayed (14 sources)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xla Wt + tbx6-VP16 (3 sources), Xla Wt + tbx6-VP16-GR + wnt8a MO (2 sources), Xtr Wt + tbx6 MO (2 sources), Xtr Wt + tbx6 MO (2 sources), Xla Wt + tbx6-EnR (1 source), Xla Wt + tbx6-VP16 (1 source), Xla Wt + tbx6-VP16-GR + DEX (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (30 sources): Abnormal morphology of female internal genitalia, Abnormal sacrum morphology, Abnormality of cardiovascular system morphology, Abnormality of the ribs, Anteverted nares, Butterfly vertebrae, Cleft palate, Disproportionate short-trunk short stature, Hemivertebrae, Hyperlordosis, [+]
Mouse (40 sources): abnormal cervical atlas morphology, abnormal cervical vertebrae morphology, abnormal digestive system development, abnormal direction of embryo turning, abnormal direction of heart looping, abnormal intersomitic artery morphology, abnormal intervertebral disk development, abnormal lumbar vertebrae morphology, abnormal mesoderm development, abnormal motile primary cilium morphology, [+]

View all ortholog results at Monarch