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Summary Expression Phenotypes Gene Literature (35) GO Terms (45) Nucleotides (77) Proteins (39) Interactants (158) Wiki
XB-GENEPAGE-6447551

scn2a     sodium channel, voltage gated, type II alpha subunit

Anatomical Phenotypes
Phenotypes manually curated with terms from the Xenopus phenotype ontology covering anatomical, gene ontology, and neurobehavioral phenotypes.
abnormal cell migration in neural crest (1 source), abnormally localised neural progenitor cell (1 source)
Expression Phenotypes
Gene expression phenotype annotations where the gene of interest has been disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1, FDR <= 0.05 and an absolute LogFC >= 2.
Manual annotations: scn2a manipulated (1 source)
Diseases
Diseases from the human disease ontology (DO) manually associated with phenotypes from disease models. Sources are grouped by anatomical (AP) and expression (EP) phenotypes.
autism spectrum disorder (1AP source, 1 EP source)
Experiments (Reagents)
These are short form descriptions of experiments using reagents targeting the gene of interest.
Xtr Wt + scn2a CRISPR (1 source)
Monarch Ortholog Phenotypes
These phenotypes are associated with this gene with a has phenotype relation via Monarch.
Human (92 sources): Abnormality of movement, Abnormality of the nervous system, Abnormality of the orbital region, Abnormality of vision, Abnormal skin morphology, Absent thumbnail, Anteverted nares, Apnea, Ataxia, Atonic seizure, [+]
Mouse (3 sources): absent gastric milk in neonates, hypoxia, postnatal lethality, complete penetrance

View all ortholog results at Monarch