| Monarch Ortholog Phenotypes
|
Human (56 sources):
Abnormal lung morphology,
Abnormality of the lymphatic system,
Abnormality of the tonsils,
Agammaglobulinemia,
Anemia,
Arthritis,
Autoimmunity,
Cellulitis,
Chronic diarrhea,
Chronic otitis media,
Conjunctivitis,
Cor pulmonale,
Decreased response to growth hormone stimulation test,
Delayed skeletal maturation,
Delayed speech and language development,
Diarrhea,
Enteroviral dermatomyositis syndrome,
Enteroviral hepatitis,
Epididymitis,
Failure to thrive,
Fatigue,
Fever,
Glossoptosis,
Hearing impairment,
Hepatitis,
Hypocalcemia,
Hypopigmented skin patches,
Immunodeficiency,
Infectious encephalitis,
Lymph node hypoplasia,
Malabsorption,
Meningitis,
Neoplasm,
Neutropenia,
Osteomyelitis,
Otitis media,
Panhypogammaglobulinemia,
Pneumonia,
Prostatitis,
Pyoderma,
Recurrent bacterial infections,
Recurrent cutaneous abscess formation,
Recurrent enteroviral infections,
Recurrent infections,
Recurrent pneumonia,
Recurrent urinary tract infections,
Sensorineural hearing impairment,
Sepsis,
Septic arthritis,
Short stature,
Sinusitis,
Skin rash,
Skin ulcer,
Thrombocytopenia,
Weight loss,
obsolete Hypotrichosis
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Mouse (31 sources):
abnormal B cell activation,
abnormal B cell proliferation,
abnormal bone marrow cell number,
abnormal humoral immune response,
abnormal lymph node germinal center morphology,
abnormal lymphopoiesis,
abnormal macrophage physiology,
abnormal pre-B cell morphology,
absent B-1a cells,
absent mature B cells,
autoimmune response,
decreased B cell proliferation,
decreased B-1 B cell number,
decreased IgG3 level,
decreased acute inflammation,
decreased follicular B cell number,
decreased immature B cell number,
decreased mature B cell number,
decreased spleen germinal center number,
decreased spleen germinal center size,
decreased splenocyte number,
decreased susceptibility to experimental autoimmune encephalomyelitis,
decreased transitional stage B cell number,
immune system phenotype,
impaired myelopoiesis,
impaired neutrophil phagocytosis,
increased CD4-positive, alpha beta T cell number,
increased immature B cell number,
increased pro-B cell number,
increased susceptibility to bacterial infection induced morbidity/mortality,
increased susceptibility to induced colitis
[+]
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View all ortholog results at Monarch
|
Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.