| Monarch Ortholog Phenotypes
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Human (42 sources):
Abnormal dental enamel morphology,
Abnormal endocardium morphology,
Abnormal fingernail morphology,
Abnormal lip morphology,
Abnormal toenail morphology,
Abnormal vagina morphology,
Abnormality of temperature regulation,
Abnormality of the immune system,
Abnormality of the mouth,
Abnormality of the nail,
Abnormality of the orbital region,
Abnormality of the skin,
Abnormality of vision,
Broad nail,
Cheilitis,
Chronic furunculosis,
Chronic mucocutaneous candidiasis,
Cough,
Cutaneous abscess,
Dyspareunia,
Erythema,
Feeding difficulties in infancy,
Folliculitis,
Hematuria,
Hemoptysis,
Hepatitis,
Hyperkeratosis,
Papule,
Pruritus,
Pustule,
Recurrent Staphylococcus aureus infections,
Recurrent bronchitis,
Recurrent cutaneous fungal infections,
Recurrent infections,
Recurrent otitis media,
Recurrent respiratory infections,
Recurrent sinusitis,
Recurrent skin infections,
Recurrent urinary tract infections,
Seizure,
Skin rash,
Skin ulcer
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Mouse (12 sources):
abnormal T-helper 2 cell differentiation,
abnormal granulocyte differentiation,
abnormal interleukin-13 secretion,
abnormal interleukin-5 secretion,
decreased interleukin-17 secretion,
decreased interleukin-9 secretion,
impaired neutrophil recruitment,
increased CD4-positive, alpha beta T cell number,
increased T-helper 17 cell number,
increased gamma-delta T cell number,
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View all ortholog results at Monarch
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Gene expression phenotype annotations where the gene of interest has been
disrupted (manipulated) or is the gene assayed (assayed). Computed annotations are derived from
differential expression analysis from Xenbase processed GEO data with the criteria of a TPM >= 1,
FDR <= 0.05 and an absolute LogFC >= 2.