Aggressive behavior, Amblyopia, Anteverted nares, Anxiety, Aspiration, Astigmatism, Attention deficit hyperactivity disorder, Autistic behavior, Bilateral ptosis, Brachycephaly, Brachydactyly, Broad hallux, Broad nasal tip, Broad thumb, Cerebral atrophy, Cerebral visual impairment, Chronic constipation, Coarse facial features, Compulsive behaviors, Cryptorchidism, Decreased response to growth hormone stimulation test, Delayed speech and language development, Depressed nasal bridge, Developmental regression, Downslanted palpebral fissures, Everted lower lip vermilion, Exotropia, Eyelid coloboma, Feeding difficulties, Floppy infant, Focal white matter lesions, Gastroesophageal reflux, Gastrostomy tube feeding in infancy, Generalized hypotonia, Generalized neonatal hypotonia, Global developmental delay, High anterior hairline, Hirsutism, Hyperactivity, Hypermetropia, Hypoplasia of the corpus callosum, Hypotonia, Impaired mastication, Intellectual disability, Iris coloboma, Juvenile cataract, Language impairment, Long palpebral fissure, Long philtrum, Low-set ears, Microcephaly, Microtia, Mild global developmental delay, Moderate global developmental delay, Motor stereotypy, Narrow palpebral fissure, Obesity, obsolete Impaired social interactions, obsolete Joint laxity, obsolete Low-set, posteriorly rotated ears, Oral-pharyngeal dysphagia, Plagiocephaly, Polydactyly, Polyphagia, Prominent forehead, Protruding ear, Ptosis, Recurrent infections, Recurrent upper respiratory tract infections, Recurrent urinary tract infections, Respiratory distress, Sandal gap, Seizure, Severe global developmental delay, Short nose, Short stature, Single transverse palmar crease, Slanting of the palpebral fissure, Sleep abnormality, Small hand, Smooth philtrum, Sparse scalp hair, Spasticity, Strabismus, Thick lower lip vermilion, Thin upper lip vermilion, Trigonocephaly, Truncal obesity, Umbilical hernia, Urinary incontinence, Ventriculomegaly, Visual impairment, Vomiting, Wide intermamillary distance, Widely spaced teeth, Wide mouth, Wide nasal bridge