Amblyopia, Anteverted nares, Anxiety, Aspiration, Astigmatism, Attention deficit hyperactivity disorder, Autistic behavior, Bilateral ptosis, Brachycephaly, Brachydactyly, Broad hallux, Broad nasal tip, Broad thumb, Cerebral atrophy, Cerebral visual impairment, Chronic constipation, Coarse facial features, Cryptorchidism, Decreased response to growth hormone stimulation test, Delayed speech and language development, Depressed nasal bridge, Developmental regression, Downslanted palpebral fissures, Everted lower lip vermilion, Exotropia, Eyelid coloboma, Feeding difficulties, Focal white matter lesions, Gastroesophageal reflux, Gastrostomy tube feeding in infancy, Generalized hypotonia, Generalized neonatal hypotonia, Global developmental delay, High anterior hairline, Hirsutism, Hyperactivity, Hypermetropia, Hypoplasia of the corpus callosum, Hypotonia, Impaired mastication, Impaired social interactions, Infantile muscular hypotonia, Intellectual disability, Iris coloboma, Joint laxity, Juvenile cataract, Language impairment, Long palpebral fissure, Long philtrum, Low-set ears, Low-set, posteriorly rotated ears, Microcephaly, Microtia, Mild global developmental delay, Moderate global developmental delay, Motor stereotypy, Narrow palpebral fissure, Neurological speech impairment, Obesity, Obsessive-compulsive behavior, Oral-pharyngeal dysphagia, Plagiocephaly, Polydactyly, Polyphagia, Prominent forehead, Protruding ear, Ptosis, Recurrent infections, Recurrent upper respiratory tract infections, Recurrent urinary tract infections, Respiratory distress, Sandal gap, Seizure, Severe global developmental delay, Short nose, Short stature, Single transverse palmar crease, Slanting of the palpebral fissure, Sleep disturbance, Small hand, Smooth philtrum, Sparse scalp hair, Spasticity, Strabismus, Thick lower lip vermilion, Thin upper lip vermilion, Trigonocephaly, Truncal obesity, Umbilical hernia, Urinary incontinence, Ventriculomegaly, Visual impairment, Vomiting, Wide intermamillary distance, Wide mouth, Wide nasal bridge, Widely spaced teeth